Increased risk of infection with human immunodeficiency virus type 1 among uncircumcised men presenting with genital ulcer disease in Kenya
Increased risk of infection with human immunodeficiency virus type 1 among uncircumcised men presenting with genital ulcer disease in Kenya
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DOI：
10.1093/clinids/23.3.449
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发表时间：
1996-09-01
影响因子：
11.8
通讯作者：
Plummer, FA
中科院分区：
文献类型：
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作者：
Tyndall, MW;Ronald, AR;Plummer, FA
造成撒哈拉以南非洲1型人体免疫机能丧失病毒（艾滋病毒-1）爆炸性蔓延的因素仍在查明和辩论之中。最具争议的因素之一是男性割礼。这项横断面研究是为了衡量包皮环切状态和感染HIV-1的男性生殖器溃疡疾病之间的关联。810名男性参与了这项研究，其中190人（23%）为HIV-1阳性。调整行为和历史因素后的逻辑回归模型显示，HIV-1阳性与未行包皮环切术（调整后的比值比[OR]，4.8; 95%置信区间[CI]，3.3-7.2）和尿道分泌物史（调整后的OR，2.0; 95% CI，1.4-2.8）独立相关。这种关联不能用这一人群中HIV-1性接触的措施来解释。男性包皮环切术应作为艾滋病控制的一种干预策略。
The factors responsible for the explosive spread of human immunodeficiency virus type 1 (HIV-1) in sub-Saharan Africa continue to be identified and debated. One of the most controversial factors has been male circumcision. This cross-sectional study was conducted to measure the association between circumcision status and infection with HIV-1 among men with genital ulcer disease. Eight hundred and ten men participated in the study, of whom 190 (23%) were HIV-1-positive. A logistic regression model adjusted for behavioral and historical factors showed that HIV-1 positivity was independently associated with being uncircumcised (adjusted odds ratio [OR], 4.8; 95% confidence interval [CI], 3.3-7.2) and with a history of urethral discharge (adjusted OR, 2.0; 95% CI, 1.4-2.8). This association could not be explained by measures of sexual exposure to HIV-1 among this population. Male circumcision should be considered as an intervention strategy for AIDS control.