Hyperinsulinemia and sympathoadrenal system activity in the rat.
Hyperinsulinemia and sympathoadrenal system activity in the rat.
复制标题
大鼠的高胰岛素血症和交感肾上腺系统活动。
DOI：
10.1111/j.1749-6632.1997.tb51827.x
复制
发表时间：
1997
影响因子：
5.2
通讯作者：
Klimes,I
中科院分区：
文献类型：
--
作者：
Kvetnanský,R;Rusnák,M;Gasperíková,D;Jeloková,J;Zórad,S;Vietor,I;Pacák,K;Seböková,E;Macho,L;Sabban,EL;Klimes,I
高胰岛素血症、胰岛素抵抗和高血压之间的关系已被描述；然而，这些现象是否存在因果关系尚不完全清楚（回顾，参见文献1-5）。在大鼠中，急性和慢性高胰岛素血症都会导致血压升高。胰岛素诱导的血压调节变化的机制可能涉及多种因素——儿茶酚胺能系统的激活、钠-液潴存、阳离子转运的调节、血管病变等。此外，一些研究者已经指出，交感神经系统在胰岛素介导的血压变化中起作用
A relationship between hyperinsulinemia, insulin resistance, and hypertension has been described; however, it is still not completely clear whether these phenomena are causally related (for review, see references 1-5). In rats, both acute and chronic hyperinsulinemia lead to an increase in blood pressure (BP). G8 The mechanisms of insulin-induced changes in BP regulation could involve several hctors-activation of catecholaminergic systems, sodium-fluid retention, modulation of cation transport, vasculopathy, etc. 5 Moreover, several investigators have indicated a role for the sympathoneural system in insulin-mediated BP~ hanges.~+~-'3