BCL-2 expression in epithelial rest of Malassez, both in vivo and in vitro
BCL-2 expression in epithelial rest of Malassez, both in vivo and in vitro
复制标题
马拉塞斯上皮其余部分的 BCL-2 表达（体内和体外）
DOI：
10.2330/joralbiosci1965.39.618
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
T. Kaku
中科院分区：
文献类型：
--
作者：
J. Arai;Y. Abiko;M. Nishimura;M. Saitoh;T. Kaku
bcl-2基因最初被发现参与B细胞淋巴瘤的t（14; 18）染色体易位。据报道，bcl-2基因产物BCL-2可阻断细胞凋亡，并参与组织发育和肿瘤发生1，2）。BCL-2在人牙胚的上皮部分中表达，除了在其完全分化的阶段形成釉质的成釉细胞3）。我们发现BCL-2在成釉细胞瘤中的定位，表明BCL-2通过阻断骨形成促进成釉细胞瘤的发展4）。这些牙源性上皮细胞中的一部分被称为马拉色上皮剩余部分，即使在牙齿发育完成后，它也能在牙周膜中维持很长的寿命。我们假设表达BCL-2的上皮休息维持其存在并逃避细胞凋亡。因此，本研究探讨了马拉色上皮休息是否在体内和体外条件下表达BCL-2。
The bcl-2 gene was originally discovered for its involvement in the t (14; 18) chromosomal translocation in B-cell lymphomas. The bcl-2 gene product, BCL-2, has been reported to block apoptosis and is involved in tissue development and tumorigenecity1,2) . The expression of BCL-2 has been demonstrated in the epithelial part of the human tooth germ except for the enamel-forming ameloblasts at their fully differentiated stage3). We showed the localization of BCL2 in ameloblastoma, suggesting that BCL-2 contributed to the development of ameloblastoma by blocking apoptosis4). A part of these odontogenic epithelial cells termed the epithelial rest of Malassez5), maintained a long life span in the periodontal ligament even after tooth development was completed. We hypothesized that the epithelial rests expressed the BCL-2 maintained their existence and escaped from apoptosis. Therefore, the present study examined whether the epithelial rests of Malassez expressed BCL-2 in both in vivo and in vitro conditions.