Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams.
Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams.
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DOI：
10.1186/1748-717x-8-57
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发表时间：
2013-03-12
期刊：
影响因子：
--
通讯作者：
Ravo V
中科院分区：
文献类型：
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作者：
Di Franco R;Sammarco E;Calvanese MG;De Natale F;Falivene S;Di Lecce A;Giugliano FM;Murino P;Manzo R;Cappabianca S;Muto P;Ravo V
这项研究的目的是在客观评估的基础上增加对放射治疗引起的皮肤损伤的工具性评估。这项研究在一年多的时间里招募了100名乳腺癌患者。将患者分为5组，每组20例。对于每一组，都开出了不同的局部治疗处方。使用的产品包括：β-葡聚糖，透明质酸钠(Neoviderm®)，欧洲葡萄(Vitis vinifera A.)S-i-m.t-O.dij(Ixoderm®)，Atlantica加乙基二亚氨基甲基愈创木酚和三氯氧锰(Radioskin1®)，金属七叶树加银杏和芦荟(Radioskin 2®)，天然甘油三酯-Fitosterol(Xderit®)，精选糖加Avene热水(TriXera+®)。所有保湿霜在放疗前15天和治疗后1个月开始，每天两次。在治疗前和治疗期间，患者每周进行皮肤评估和角膜测量，以评估与皮肤毒性和水合状态相关的症状。急性皮肤毒性评价以RTOG评分为标准。所有患者都完成了放射治疗；72%的患者出现G1级皮肤毒性，18%的患者出现G2级皮肤毒性，10%的患者出现G3级毒性，没有人出现G4级毒性。角膜测量学研究证实了乳腺癌放射治疗中使用的有效乳膏的保护作用，并显示了其在非常早期阶段识别辐射引起的皮炎的有效性。预防性使用主题产品可降低接受乳腺癌放射治疗的患者皮肤副作用的发生率。对皮肤水合的仪器评估可以帮助放射肿瘤学家使用策略，防止高度毒性的发生。在这项研究中使用的所有保湿霜在治疗放射治疗引起的皮肤损伤方面都同样有效。
The purpose of this study was to add, to the objective evaluation, an instrumental assessment of the skin damage induced by radiation therapy. A group of 100 patients affected by breast cancer was recruited in the study over one year. Patients were divided into five groups of 20 patients. For each group it was prescribed a different topical treatment. The following products were used: Betaglucan, sodium hyaluronate (Neoviderm®), Vitis vinifera A. s-I-M.t-O.dij (Ixoderm®), Alga Atlantica plus Ethylbisiminomethylguaicolo and Manganese Cloruro (Radioskin1®) and Metal Esculetina plus Ginko Biloba and Aloe vera (Radioskin 2®); Natural triglycerides-fitosterols (Xderit®); Selectiose plus thermal water of Avene (Trixera+®). All hydrating creams were applied twice a day starting 15 days before and one month after treatment with radiations. Before and during treatment patients underwent weekly skin assessments and corneometry to evaluate the symptoms related to skin toxicity and state of hydration. Evaluation of acute cutaneous toxicity was defined according to the RTOG scale. All patients completed radiotherapy; 72% of patients presented a G1 cutaneous toxicity, 18% developed a G2 cutaneous toxicity, 10% developed a G3 toxicity, no one presented G4 toxicity. The corneometry study confirmed the protective role of effective creams used in radiation therapy of breast cancer and showed its usefulness to identify radiation-induced dermatitis in a very early stage. The preventive use of topic products reduces the incidence of skin side effects in patients treated with radiotherapy for breast cancer. An instrumental evaluation of skin hydration can help the radiation oncologist to use strategies that prevent the onset of toxicity of high degree. All moisturizing creams used in this study were equally valid in the treatment of skin damage induced by radiotherapy.