FLASH ELECTRORETINOGRAM ABNORMALITIES IN PATIENTS WITH CLINICALLY DEFINITE MULTIPLE-SCLEROSIS
FLASH ELECTRORETINOGRAM ABNORMALITIES IN PATIENTS WITH CLINICALLY DEFINITE MULTIPLE-SCLEROSIS
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DOI：
10.1017/s0317167100044152
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发表时间：
1982-01-01
影响因子：
3
通讯作者：
KIRKHAM, TH
中科院分区：
文献类型：
--
作者：
COUPLAND, SG;KIRKHAM, TH
本文对105例多发性硬化患者的闪光视网膜电图（ERG）进行了研究。他们被分为4组。第1组无视神经功能障碍的病史或临床证据，第2组和第3组分别有左侧或右侧视神经疾病，第4组有双侧视神经疾病的病史或临床证据。采用方差分析（ANOVA）对数据进行统计学分析，结果表明，无视神经疾病病史或临床证据的患者组与对照组的峰值b波隐式时间无显著差异，但其他3组患者的患侧明显延迟。Mann-Whitney U检验显示，所有4个患者组与对照组相比，绝对眼间潜伏期差异显著更大。还研究了视网膜电图对闪光VEP [视觉诱发电位]延迟的贡献。在单侧或双侧视神经疾病的患者中，闪光VEP延迟的患者中有14-31%也显示ERG b波异常延长。这些结果证实了多发性硬化患者视网膜功能障碍的高发病率，并可能表明视神经脱髓鞘发生视网膜结构的跨突触变性。特别是显著的绝对眼间潜伏期差异可以提供另一个电生理参数，以在可疑病例中建立多发性硬化症的诊断。
The flash electroretinograms (ERG) of 105 patients with multiple sclerosis were studied. They were divided into 4 groups. The 1st group had no history or clinical evidence of optic nerve dysfunction, the 2nd and 3rd groups had either left or right optic nerve disease respectively and the 4th group had historical or clinical evidence of bilateral optic nerve disease. Statistical analysis of the data, using analysis of variance (ANOVA), showed that the group of patients with no history or clinical evidence of optic nerve disease had no significance difference from the control group for their peak b-wave implicit times but the other 3 groups were significantly delayed on the affected side(s). The Mann-Whitney U-test showed that all 4 patient groups had significantly greater absolute interocular latency differences from the control group. The electroretinal contribution to flash VEP [visual evoked potential] delay was also investigated. In patients with unilateral or bilateral optic nerve disease, 14-31% of those with flash VEP delay also showed abnormal prolongation of the ERG b-wave. These results confirm a high incidence of retinal dysfunction in multiple sclerosis patients and may suggest that transynaptic degeneration of retinal structures occurs in optic nerve demyelination. The significant absolute interocular latency difference in particular may provide another electrophysiological parameter to establish a diagnosis of multiple sclerosis in suspect cases.