Frequency and Significance of Coronary Artery Disease and Myocardial Bridging in Patients With Hypertrophic Cardiomyopathy
Frequency and Significance of Coronary Artery Disease and Myocardial Bridging in Patients With Hypertrophic Cardiomyopathy
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DOI：
10.1016/j.amjcard.2020.02.002
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发表时间：
2020-05-01
影响因子：
2.8
通讯作者：
Hirsch, Alexander
中科院分区：
文献类型：
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作者：
van der Velde, Nikki;Huurman, Roy;Hirsch, Alexander
肥厚性心肌病（HC）胸痛的病因多种多样，包括冠状动脉疾病（CAD）以及HC特异性原因。心肌桥接（MB）与HC、胸痛和动脉粥样硬化加速有关。我们将HC患者与年龄、性别和CAD测试前概率匹配的胸痛门诊患者进行比较，利用冠状动脉计算机断层血管造影（CCTA）研究MB和CAD存在的差异。我们研究了84例接受CCTA的HC患者，并将其与168例匹配的对照组（年龄54 +/- 11岁，70%为男性，检测前概率为12%[5%至32%]）进行比较。评估每位患者的MB、钙评分、斑块形态以及CAD的存在和程度。线性混合模型用于评估病例和对照组之间的差异。MB在HC患者中更为常见(50% vs 25%, p
The etiology of chest pain in hypertrophic cardiomyopathy (HC) is diverse and includes coronary artery disease (CAD) as well as HC-specific causes. Myocardial bridging (MB) has been associated with HC, chest pain, and accelerated atherosclerosis. We compared HC patients with age-, gender- and CAD pre-test probability-matched outpatients presenting with chest pain to investigate differences in the presence of MB and CAD using coronary computed tomography angiography (CCTA). We studied 84 HC patients who underwent CCTA and compared these with 168 matched controls (age 54 +/- 11 years, 70% men, pre-test probability 12% [5% to 32%]). MB, calcium score, plaque morphology and presence and extent of CAD were assessed for each patient. Linear mixed models were used to assess differences between cases and controls. MB was more often seen in HC patients (50% vs 25%, p