SHORT-DURATION EXPOSURE AND THE TRANSMISSION OF RHINOVIRAL COLDS
SHORT-DURATION EXPOSURE AND THE TRANSMISSION OF RHINOVIRAL COLDS
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DOI：
10.1093/infdis/150.2.189
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发表时间：
1984-01-01
影响因子：
6.4
通讯作者：
DICK, EC
中科院分区：
文献类型：
--
作者：
DALESSIO, DJ;MESCHIEVITZ, CK;DICK, EC
在26名实验感染的供体和33名无抗体（滴度< 1：3）受体之间的自然相互作用情况下，尝试了55型鼻病毒感染的传播。在总共3个实验中，只有2个受体（6%）被感染。在第一个实验中，在一个小房间里大声喊叫和打牌2-3小时后，没有发生从5个供体到9个受体的传输。在第二次实验中，感冒传播到1（9%）的11个收件人住在宿舍房间36小时，主要由2个捐助者和2个收件人组成的组。在第三次实验中，13名受体中有1名（8%）在亲吻受感染的供体后感染。在鼻病毒16型研究中，发现鼻中的中位人类感染剂量为0.28 TCID 50（中位组织培养感染剂量），舌中为2260 TCID 50，外鼻孔中为11，000 TCID 50。鼻病毒感染很难通过短期自然暴露传播，这可能是因为该病原体必须以压倒性的数量存在才能到达易感的粘膜细胞。
Transmission of infection with rhinovirus type 55 was attempted under natural circumstances of interaction among 26 experimentally infected donors and 33 antibody-free (titer, < 1:3) recipients. In a total of 3 experiments, only 2 recipients (6%) became infected. In the 1st experiment no transmissions from 5 donors to 9 recipients occurred after 2-3 h of loud vocalization and card playing in a small room. In the 2nd experiment a cold was transmitted to 1 (9%) of 11 recipients living in dormitory rooms for 36 h in groups consisting chiefly of 2 donors and 2 recipients. In the 3rd experiment, 1 (8%) of 13 recipients was infected after kissing an infected donor. In studies with rhinovirus type 16, the median human infectious dose was found to be 0.28 TCID50 (median tissue culture infectious dose) in the nose, 2260 TCID50 on the tongue and 11,000 TCID50 on the external nares. Rhinoviral infections are difficult to transmit by short-term natural exposure, perhaps because the agent must be present in overwhelming numbers to reach susceptible mucosal cells.