Molecular epidemiology of coxsackievirus B3 infection in Spain, 2004-2014
Molecular epidemiology of coxsackievirus B3 infection in Spain, 2004-2014
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DOI：
10.1007/s00705-016-2783-1
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发表时间：
2016-05-01
影响因子：
2.7
通讯作者：
Cabrerizo, Maria
中科院分区：
文献类型：
--
作者：
Calderon, Katherine I.;Diaz-de Cerio, Maria;Cabrerizo, Maria
对西班牙柯萨奇B3病毒感染的流行病学和临床特征进行了调查。这种肠道病毒（EV）类型主要在幼儿（< 6个月）中检测到，与神经系统疾病（78%）和呼吸系统疾病（10%）有关，但也与心肌/心包炎（10%）有关。2例心肌炎病例为致死性。对VP 1区域的系统发育分析显示，2004年至2008年期间，基因型III在该国流行，并于2010年被基因型V取代。此外，系统发育分析的3D区域表明，重组事件已经发生，并有助于这种EV类型的遗传进化。
Epidemiological and clinical characteristics of coxsackievirus B3 infections in Spain were investigated. This enterovirus (EV) type was detected mainly in young children (< 6 months) and was associated with neurological (78 %) and respiratory diseases (10 %) but also with myo/pericarditis (10 %). Two myocarditis cases were fatal. Phylogenetic analysis of the VP1 region showed that genotype III circulated in the country between 2004 and 2008 and was replaced by genotype V in 2010. Furthermore, phylogenetic analysis of the 3D region indicated that recombination events have occurred and contributed to the genetic evolution of this EV type.