Catalytic Aza-Wacker Annulation: Tuning Mechanism by the Activation Mode of Amide and Enantioselective Syntheses of Melinonine-E and Strychnoxanthine
Catalytic Aza-Wacker Annulation: Tuning Mechanism by the Activation Mode of Amide and Enantioselective Syntheses of Melinonine-E and Strychnoxanthine
复制标题
催化 Aza-Wacker 环化：酰胺激活模式的调节机制以及 Melinonine-E 和马钱子黄嘌呤的对映选择性合成
DOI：
10.1021/acs.orglett.8b00725
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发表时间：
2018
期刊：
影响因子：
5.2
通讯作者：
Hong Ran
中科院分区：
文献类型：
--
作者：
Xie Chanmin;Luo Jisheng;Zhang Yuping;Huang Sha-Hua;Zhu Lili;Hong Ran
发现了一个前所未有的酰胺的N-取代基对于环化反应的成功至关重要，从而以较高的产率建立了2-氮杂双环[3.3.1]壬烷和其他环状骨架。在甜蜜素-E和士的诺黄嘌呤的简明合成和绝对构型测定中，进一步说明了新的催化氮杂-瓦克环化方法。
An unprecedented N-substituent of the amide was found to be crucial for the successful annulation to establish 2-azabicyclo[3.3.1]nonane and other ring skeletons in good yield. The novel catalytic aza-Wacker annulation methodology was further illustrated in the concise syntheses and the absolute configuration determinations of melinonine-E and strychnoxanthine.