INDUCTION OF AIDS-LIKE DISEASE IN MACAQUE MONKEYS WITH T-CELL TROPIC RETROVIRUS STLV-III
INDUCTION OF AIDS-LIKE DISEASE IN MACAQUE MONKEYS WITH T-CELL TROPIC RETROVIRUS STLV-III
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DOI：
10.1126/science.2412295
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
KING, NW
中科院分区：
文献类型：
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作者：
LETVIN, NL;DANIEL, MD;KING, NW
猕猴（Macaca mulatta）的t细胞嗜性逆转录病毒STLV-III具有形态学、生长和抗原特性，表明它与HTLV-III/LAV（人类获得性免疫缺陷综合征（AIDS）的病原）有关。接种stv - iii后160天内，6只恒河猴中有4只死亡，并出现消耗综合征、机会性感染、原发性逆转录病毒脑炎和免疫异常，包括T4+外周血淋巴细胞减少。这些数据表明，一种来自HTLV-III/LAV组逆转录病毒的试剂可以在非人灵长类动物中实验性地产生免疫缺陷综合征。因此，stlv - iii -猕猴系统将为人类艾滋病抗病毒药物的研究和疫苗的开发提供一个有用的模型。
The T-cell tropic retrovirus of macaque monkeys [Macaca mulatta] STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4+ peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.