EFFECTS OF BRIEF STARVATION ON MUSCLE AMINO-ACID METABOLISM IN NONOBESE MAN
EFFECTS OF BRIEF STARVATION ON MUSCLE AMINO-ACID METABOLISM IN NONOBESE MAN
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DOI：
10.1172/jci108295
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发表时间：
1976-01-01
影响因子：
15.9
通讯作者：
TOBIN, JD
中科院分区：
文献类型：
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作者：
POZEFSKY, T;TANCREDI, RG;TOBIN, JD
从骨骼肌中释放的底物氨基酸的减少在很大程度上解释了以长时间饥饿为特征的骨异生的减少。短暂的饥饿与肌肉再生的增加有关，表明肌肉中氨基酸的释放增加。在目前的研究中，从骨骼肌的短暂饥饿诱导的加速氨基酸释放试图解释伴随的增强的胚胎发生。为此，在15名吸收后（禁食过夜）受试者和7名禁食60 h受试者中对前臂肌肉的氨基酸平衡进行了定量。禁食显著降低基础胰岛素（11.3-7.5 μ U/ml）和增加胰高血糖素（116-134 pg/ml）。肌肉释放的主要糖原氨基酸增加。丙氨酸释放增加59.4%。所有氨基酸的释放平均增加69.4%，并且对于苏氨酸、丝氨酸、甘氨酸、丙氨酸、α-氨基丁酸、甲硫氨酸、酪氨酸和赖氨酸具有统计学显著性。因此，在短暂饥饿的情况下，肌肉释放的糖原氨基酸显著增加。这与表征长期饥饿的氨基酸释放减少形成对比。外周组织代谢对短暂饥饿的适应最好用胰岛素的减少来解释。
A reduction in the release of substrate amino acids from skeletal muscle largely explains the decrease in gluconeogenesis characterizing prolonged starvation. Brief starvation is associated with an increase in gluconeogenesis, suggesting increased release of amino acids from muscle. In the present studies, accelerated amino acid release from skeletal muscle induced by brief starvation was sought to account for the accompanying augmentation of gluconeogenesis. To do this amino acid balance across forearm muscles was quantified in 15 postabsorptive (overnight fasted) subjects and in 7 subjects fasted for 60 h. Fasting significantly reduced basal insulin (11.3-7.5 muU/ml) and increased glucagon (116-134 pg/ml). Muscle release of the principal glycogenic amino acids increased. Alanine release increased 59.4%. The increase in release for all amino acids averaged 69.4% and was statistically significant for threonine, serine, glycine, alanine, alpha-aminobutyrate, methionine, tyrosine, and lysine. Thus, with brief starvation, muscle release of glycogenic amino acids increases strikingly. This contrasts with the reduction of amino acid release characterizing prolonged starvation. The adaptation of peripheral tissue metabolism to brief starvation is best explained by the decrease in insulin.