Cerebral venous and arterial blood volumes can be estimated separately in humans using magnetic resonance imaging
Cerebral venous and arterial blood volumes can be estimated separately in humans using magnetic resonance imaging
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DOI：
10.1002/mrm.10257
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发表时间：
2002-10-01
影响因子：
3.3
通讯作者：
Lin, WL
中科院分区：
文献类型：
--
作者：
An, HY;Lin, WL
提出了分别定量、无创估计人类总脑血容量（tCBV）和脑静脉血容量（vCBV）的方法。使用了两种序列，包括3D高分辨率梯度回波（GE）序列和2D多回波GE/自旋回波（MEGESE）序列。通过前一个序列获得的图像提供了背景磁场变化（DeltaB）的估计值，而通过后一个序列获得的图像用于获得有和无造影剂的tCBV和vCBV的单独测量值。在计算vCBV和tCBV之前，对采集的图像进行了校正，以消除由于DeltaB的存在而引起的信号损失。AB校正后，vCBV和tCBV估计值分别为2.46% +/- 0.28%和3.20% +/-0.41%，vCBV/tCBV比值为0.77 +/- 0.04，与文献中报告的结果非常一致。我们的研究结果表明，定量估计的vCBV和tCBV可以在体内获得。(C)2002 Wiley-Liss，Inc.
Approaches to obtain quantitative, noninvasive estimates of total cerebral blood volume (tCBV) and cerebral venous blood volume (vCBV) separately in humans are proposed. Two sequences were utilized, including a 3D high-resolution gradient-echo (GE) sequence and a 2D multi-echo GE/spin-echo (MEGESE) sequence. Images acquired by the former sequence provided an estimate of background magnetic field variations (DeltaB), while images obtained by the latter sequence were utilized to obtain separate measures of tCBV and vCBV with and without contrast agent. Prior to the calculation of vCBV and tCBV, the acquired images were corrected for signal loss induced by the presence of DeltaB. vCBV and tCBV were estimated to be 2.46% +/- 0.28% and 3.20% +/- 0.41 %, respectively, after the AB correction, which in turn provided a vCBV/tCBV ratio of 0.77 +/- 0.04, in excellent agreement with results reported in the literature. Our results demonstrate that quantitative estimates of vCBV and tCBV can be obtained in vivo. (C) 2002 Wiley-Liss, Inc.