Olfactory sensory neurons in the sea lamprey display polymorphisms
Olfactory sensory neurons in the sea lamprey display polymorphisms
复制标题
DOI：
10.1016/j.neulet.2006.12.037
复制
发表时间：
2007-03-13
影响因子：
2.5
通讯作者：
Zielinski, B. S.
中科院分区：
文献类型：
--
作者：
Laframboise, A. J.;Ren, X.;Zielinski, B. S.
七鳃鳗(Petromyzon Marinus)是一种古老的无颌鱼，是从现代(硬骨鱼)鱼类中分离出来的。它是研究嗅觉的一个很好的生物，因为它的嗅觉通路很容易被操纵，而且它在脊椎动物进化中的重要位置。所有鱼类的嗅觉系统都有许多相似之处，它们也与哺乳动物的嗅觉系统有共同的特点。硬骨鱼缺乏哺乳动物特有的犁鼻器；相反，所有气味最初都是由嗅觉上皮内三种形态的嗅觉神经元(OSN)处理的。我们试图确定海鳗的嗅觉感觉神经元的多态性。利用将染料注入嗅球的逆行示踪，我们鉴定出三种形态类型，它们与硬骨鱼中发现的高度相似。这项研究首次提供了七鳃鳗外周嗅觉器官形态类型的证据，并表明嗅觉神经元多态可能是脊椎动物进化过程中高度保守的特征。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
The sea lamprey (Petromyzon marinus) is an ancient jawless fish phyletically removed from modern (teleost) fishes. It is an excellent organism in the study of olfaction due to its accessible olfactory pathway, which is susceptible to manipulation, and its important location in the evolution of vertebrates. There are many similarities in the olfactory systems of all fishes, and they also share characteristics with the olfactory system of mammals. Teleost fishes lack the distinctive vomeronasal organ of mammals; rather all odours are processed initially by olfactory sensory neurons (OSNs) of three morphotypes within the olfactory epithelium. We sought to identify olfactory sensory neuron polymorphisms in the sea lamprey. Using retrograde tracing with dyes injected into the olfactory bulb, we identified three morphotypes which are highly similar to those found in teleosts. This study provides the first evidence of morphotypes in the sea lamprey peripheral olfactory organ, and indicates that olfactory sensory neuron polymorphism may be a trait highly conserved throughout vertebrate evolution. (c) 2007 Elsevier Ireland Ltd. All rights reserved.