Evolution of the vertebrate ParaHox clusters
Evolution of the vertebrate ParaHox clusters
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DOI：
10.1002/jez.b.21099
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发表时间：
2006-09-15
影响因子：
2.2
通讯作者：
Stadler, Peter F.
中科院分区：
文献类型：
--
作者：
Prohaska, Sonja J.;Stadler, Peter F.
ParaHox簇包含三个与Hox相关的同源框基因。在后生动物中，这个HOX基因簇姐妹的进化已经被广泛研究，重点是它的早期进化。然而，它在脊椎动物谱系中的命运，特别是在硬骨鱼特有的基因组复制之后，并没有得到太多的关注。人类的四个ParaHox基因座中有三个与PDGFR家族的酪氨酸激酶连锁。我们证明，这些基因座在祖先脊椎动物中以重复的形式出现，并追溯了随后的基因丢失历史。令人惊讶的是，硬骨鱼在硬骨鱼特定的基因组复制后并没有扩大他们的ParaHox谱系，而相关的酪氨酸激酶的复制仍然存在，这支持了大规模复制之后伴随着广泛的基因丢失的假说。
The ParaHox cluster contains three Hox-related homeobox genes. The evolution of this sister of the Hox-gene clusters has been studied extensively in metazoans with a focus on its early evolution. Its fate within the vertebrate lineage, and in particular following the teleost-specific genome duplication, however, has not received much attention. Three of the four human ParaHox loci are linked with PDGFR family tyrosine kinases. We demonstrate that these loci arose as duplications in an ancestral vertebrate and trace the subsequent history of gene losses. Surprisingly, teleost fishes have not expanded their ParaHox repertoire following the teleost-specific genome duplication, while duplicates of the associated tyrosine kinases have survived, supporting the hypothesis of a large-scale duplication followed by extensive gene loss.