Phylogenetic analysis of serotype A foot-and-mouth disease virus isolated in India between 1977 and 2000
Phylogenetic analysis of serotype A foot-and-mouth disease virus isolated in India between 1977 and 2000
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DOI：
10.1007/s007050200002
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发表时间：
2002-01-01
影响因子：
2.7
通讯作者：
Venkataramanan, R
中科院分区：
文献类型：
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作者：
Tosh, C;Sanyal, A;Venkataramanan, R
通过VP 1基因序列测定，研究了1977-2000年印度A型口蹄疫病毒（FMDV）分离株的遗传多样性。根据83条印度序列和37条其它序列构建的系统发育树显示，A型口蹄疫病毒可分为10个主要基因型（命名为I-X）。印度分离株分布在4种基因型（I、IV、VI和VII）中，从结果中可以看出，近年来在该国不同州至少有2种基因型（VI和VII）共同流通。该研究还揭示了基因型的不同地理分布，例如，一些（基因型I和VII）是从大的地理区域回收的，有时甚至跨越大陆，这表明病毒的传播超越了大陆屏障。在研究中还观察到局限于特定国家的基因型（基因型III和X）的本地化。田间分离株的遗传多样性与已知抗原位点的氨基酸取代有关。这项工作提供了有价值的见解A型口蹄疫病毒在印度的流行病学情况和必要的信息，在选择合适的疫苗株（S），如果需要的话，为国家口蹄疫控制计划。
The genetic diversity among the Indian serotype A Foot-and-mouth disease virus (FMDV) isolates sampled over a period of 24 years (1977-2000) was studied by sequencing the VP1 gene. In the phylogenetic tree, constructed from 83 Indian and 37 other available sequences, the FMDV type A isolates were distributed into 10 major genotypes (designated as I-X). The Indian isolates were distributed in 4 genotypes (I, IV, VI and VII), and co-circulation of at least 2 genotypes (VI and VII) in different states of the country in recent years is evident from the result. The study also revealed differential geographic distribution of genotypes, for example, some (genotypes I and VII) were recovered from large geographical areas, some time even across the continents, suggesting the spread of the viruses beyond continental barriers. Localization of genotypes restricting to a particular country (genotypes III and X) was also observed in the study. The genetic diversity in the field isolates has been discussed in relation to the amino acid substitutions at the known antigenic sites. This work provides valuable insights into the epidemiological situation of type A FMDV in India and necessary information in the selection of suitable vaccine strain(s), if required, for the National FMD control program.