Mineral heterogeneity has a minor influence on the apparent elastic properties of human cancellous bone: a SRμCT-based finite element study
Mineral heterogeneity has a minor influence on the apparent elastic properties of human cancellous bone: a SRμCT-based finite element study
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DOI：
10.1080/10255842.2011.581236
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发表时间：
2012-01-01
影响因子：
1.6
通讯作者：
Zysset, Philippe K.
中科院分区：
文献类型：
--
作者：
Gross, Thomas;Pahr, Dieter H.;Zysset, Philippe K.
在组织水平上，由于不断的重塑，人类松质骨的局部材料特性是不均匀的。由于标准的高分辨率计算机断层扫描方法无法详细捕获这种异质性，因此矿化的局部差异通常不会纳入计算模型。为了研究非均质矿物分布对股骨颈松质骨表观弹性性能的影响，采用同步辐射微计算机断层扫描（SR mu CT）对40例股骨颈松质骨进行了扫描。将考虑矿物非均质性的SR mu ct微力学有限元模型与均质模型进行比较。对两种模型的表观刚度张量的评估表明，均质模型导致非均质模型弹性特性的高估幅度较小但显著（p < 0.05），高估幅度为2.18±1.89%。模型参数的变化对高估影响不大。结果表明，非均质矿化对松质骨的表观弹性性能影响不大。
At the tissue level, the local material properties of human cancellous bone are heterogeneous due to constant remodelling. Since standard high-resolution computed tomography scanning methods are unable to capture this heterogeneity in detail, local differences in mineralisation are normally not incorporated in computational models. To investigate the effects of heterogeneous mineral distribution on the apparent elastic properties, 40 cancellous bone samples from the human femoral neck were scanned by means of synchrotron radiation microcomputed tomography (SR mu CT). SR mu CT-based micromechanical finite element models that accounted for mineral heterogeneity were compared with homogeneous models. Evaluation of the apparent stiffness tensor of both model types revealed that homogeneous models led to a minor but significant (p < 0.05) overestimation of the elastic properties of heterogeneous models by 2.18 +/- 1.89%. Variation of modelling parameters did not affect the overestimation to a great extent. It was concluded that the heterogeneous mineralisation has only a minor influence on the apparent elastic properties of human cancellous bone.