The cellular and circuit basis for evolutionary change in sensory perception in mormyrid fishes.
The cellular and circuit basis for evolutionary change in sensory perception in mormyrid fishes.
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DOI：
10.1038/s41598-017-03951-y
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发表时间：
2017-06-19
影响因子：
4.6
通讯作者：
Carlson BA
中科院分区：
文献类型：
--
作者：
Vélez A;Kohashi T;Lu A;Carlson BA
感知的物种差异与感觉通路的大体神经解剖学特征的分歧有关。然而，在细胞和回路水平上感觉处理的进化变化的解剖学和生理学基础却知之甚少。在这里，我们展示了如何具体的变化，感觉微电路与一种新的感知能力的进化。在长颌鱼中，检测电通信信号变化的能力与中脑外外侧核（EL）的扩大以及分化成单独的前部（ELa）和后部（ELp）区域相关。我们发现，在EL和ELa/ELp相同的细胞类型和连接。ELa/ELp的进化以及伴随的检测信号变化的能力与传入后脑轴突的延长以形成延迟线相关，从而允许对信号进行精细的时间分析。这个大脑区域的扩大也可能是由于细胞数量的整体增加，这将允许处理更广泛的时间信息。
Species differences in perception have been linked to divergence in gross neuroanatomical features of sensory pathways. The anatomical and physiological basis of evolutionary change in sensory processing at cellular and circuit levels, however, is poorly understood. Here, we show how specific changes to a sensory microcircuit are associated with the evolution of a novel perceptual ability. In mormyrid fishes, the ability to detect variation in electric communication signals is correlated with an enlargement of the midbrain exterolateral nucleus (EL), and a differentiation into separate anterior (ELa) and posterior (ELp) regions. We show that the same cell types and connectivity are found in both EL and ELa/ELp. The evolution of ELa/ELp, and the concomitant ability to detect signal variation, is associated with a lengthening of incoming hindbrain axons to form delay lines, allowing for fine temporal analysis of signals. The enlargement of this brain region is also likely due to an overall increase in cell numbers, which would allow for processing of a wider range of timing information.