CD19 - LOWERING THE THRESHOLD FOR ANTIGEN RECEPTOR STIMULATION OF LYMPHOCYTES-B
CD19 - LOWERING THE THRESHOLD FOR ANTIGEN RECEPTOR STIMULATION OF LYMPHOCYTES-B
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DOI：
10.1126/science.1373518
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发表时间：
1992-04-03
期刊：
影响因子：
56.9
通讯作者：
FEARON, DT
中科院分区：
文献类型：
--
作者：
CARTER, RH;FEARON, DT
淋巴细胞必须增殖和分化，以响应低浓度的大量抗原。广泛的特异性和灵敏度的要求冲突，因为前者是由低亲和力的抗原受体，这排除了实现后者与高亲和力的受体。膜蛋白CD 19与B淋巴细胞的抗原受体的共结合使抗原受体依赖性刺激的阈值降低了两个数量级。当每个细胞中约有100个抗原受体（占总数的0.03%）与CD 19结合时，B淋巴细胞增殖。B细胞通过具有辅助蛋白来解决其困境，该辅助蛋白在很少抗原受体被占据时能够激活。
Lymphocytes must proliferate and differentiate in response to low concentrations of a vast array of antigens. The requirements of broad specificity and sensitivity conflict because the former is met by low-affinity antigen receptors, which precludes achieving the latter with high-affinity receptors. Coligation of the membrane protein CD19 with the antigen receptor of B lymphocytes decreased the threshold for antigen receptor-dependent stimulation by two orders of magnitude. B lymphocytes proliferated when approximately 100 antigen receptors per cell, 0.03 percent of the total, were coligated with CD19. The B cell resolves its dilemma by having an accessory protein that enables activation when few antigen receptors are occupied.