Epidemiology of neonatal necrotising enterocolitis:: a population-based study
Epidemiology of neonatal necrotising enterocolitis:: a population-based study
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DOI：
10.1046/j.1365-3016.2002.00445.x
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发表时间：
2002-10-01
影响因子：
2.8
通讯作者：
Kendig, JW
中科院分区：
文献类型：
--
作者：
Llanos, AR;Moss, ME;Kendig, JW
我们研究了纽约州北部一个定义明确的六县围产期地区的新生儿体重、性别和种族特定发病率以及坏死性小肠结肠炎(NEC)的生物人口学和临床相关性。我们进行了一项为期8年的基于人群的回顾性调查，以确定该地区新生儿重症监护病房(NICU)中所有确诊的NEC病例(改良Bell II期及以上)。用于计算发病率的分母是从全州规划研究合作系统中获得的。发病率表示为每1000名活产儿中有病例。在8年间经历了117892例活产的6个县围产期地区，总共确认了85例有记录的非霍奇金淋巴瘤病例。年平均发病率为0.72/1000活产儿[95%可信区间0.57，0.87/1000活产儿]。新生儿NEC发病率最高的是出生时体重750-1000克的婴儿，并随着出生体重的增加而下降。城市县患NEC的风险是农村县的1.53倍[95%可信区间0.9，2.6]。非西班牙裔黑人的NEC总发病率显著高于非西班牙裔白人(2.2例/1000活产例，P=0.00)。即使在对出生体重进行校正后，这些差异在统计上仍具有显著意义。大多数病例(93%)是早产儿(胎龄
We examined the birthweight-, gender- and race-specific incidence as well as the biodemographic and clinical correlates of necrotising enterocolitis (NEC) in a well-defined six-county perinatal region in upstate New York. We conducted a retrospective, 8-year population-based survey to identify all cases of proven NEC (modified Bell stage II and above) in the area's regional neonatal intensive care unit (NICU). The denominator used to calculate the incidence was obtained from the Statewide Planning Research Cooperative System. Incidence was expressed as cases per 1000 live births. A total of 85 documented cases of proven NEC was identified in a six-county perinatal region that experienced 117892 live births during the 8-year period. The average annual incidence was 0.72 cases per 1000 live births [95% CI 0.57, 0.87 per 1000 live births]. The highest incidence of NEC occurred among infants weighing 750-1000 g at birth and declined with increasing birthweight. The urban county had a 1.53 times higher risk of NEC than rural counties [95% CI 0.9, 2.6]. The overall incidence of NEC for non-Hispanic blacks was significantly greater than that for non-Hispanic whites (2.2 vs. 0.5 cases per 1000 live births, P = 0.00). The differences remained statistically significant even after correction for birthweight. Most cases (93%) in this series were preterm (gestational age