Effect of intravenous administration of dipyridamole in a rat model of chronic cerebral ischemia
Effect of intravenous administration of dipyridamole in a rat model of chronic cerebral ischemia
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DOI：
10.1111/j.1749-6632.2010.05732.x
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发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Pedata, Felicita
中科院分区：
文献类型：
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作者：
Melani, Alessia;Cipriani, Sara;Pedata, Felicita
能够改善慢性血管病变患者认知能力的药物治疗目前仍不可用。许多关于啮齿类动物慢性脑性低血压的研究揭示了参考记忆和学习的改变。双嘧达莫于20世纪60年代初作为冠状动脉血管扩张剂引入临床。它是一种有效的血小板活化抑制剂，可减少体内血栓的形成。此外，它是一种抗血栓形成药物，与阿司匹林联合用于二级卒中预防。最近的证据表明，双嘧达莫具有抗炎特性。大鼠双侧颈总动脉闭塞（2VO）被认为是慢性脑低血压的有效模型，也被定义为“血管性认知障碍大鼠模型”。“在这里，我们报告说，潘生丁逆转了2VO后90天的空间工作记忆障碍。这种保护作用可能与双嘧达莫的抗炎特性有关。
Pharmacological therapy able to improve the cognitive performances of patients with chronic vascular pathologies currently remains unavailable. Many studies of chronic cerebral hypotension in rodents have revealed alterations in reference memory and learning. Dipyridamole was introduced into clinical medicine in the early 1960s as a coronary vasodilator. It is a potent inhibitor of platelet activation and reduces formation of thrombi in vivo. In addition, it is an antithrombotic agent used for secondary stroke prevention in combination with aspirin. Recent evidence indicates that dipyridamole has anti-inflammatory properties. Bilateral common carotid artery occlusion (2VO) in the rat is recognized as a valid model of chronic cerebral hypotension, also defined as the "vascular cognitive impairment rat model." Here, we report that dipyridamole reverses the impairment of spatial working memory 90 days after 2VO. This protective effect might be in relation to dipyridamole's anti-inflammatory properties.