Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract
Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract
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DOI：
10.1016/j.reprotox.2007.07.006
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发表时间：
2007-08-01
影响因子：
3.3
通讯作者：
Padilla-Banks, Elizabeth
中科院分区：
文献类型：
--
作者：
Newbold, Retha R.;Jefferson, Wendy N.;Padilla-Banks, Elizabeth
发育中的胎儿对具有激素样活性的化学物质的干扰特别敏感。产前暴露于己烯雌酚（DES）的不良影响就是一个典型的例子。由于人们越来越关注双酚A（BPA）对人类健康和环境的影响，双酚A是一种用于合成塑料的具有雌激素活性的高产量化学品，我们研究了其在实验动物模型中的长期影响，该模型先前在研究发育暴露于DES的不良影响中显示出有用。在第1-5天，用溶解在玉米油中的BPA（10、100或1000 μ g/kg/天）或单独的玉米油（对照）皮下注射处理远交雌性CD-1小鼠。18个月时，检查卵巢和生殖道组织。与对照组相比，BPA-100组中囊性卵巢和囊性子宫内膜增生（CEH）在统计学上显著增加。在所有BPA组中还观察到输卵管和囊性中肾（Wolffian）管残留物的进行性增生性病变（PPL）。新生儿BPA治疗后更严重的子宫病变包括子宫腺肌病、平滑肌瘤、不典型增生和间质息肉。这些数据表明，如果在分化的关键时期暴露于BPA，会导致长期的不良影响。爱思唯尔公司出版
The developing fetus is uniquely sensitive to perturbation by chemicals with hormone-like activity. The adverse effects of prenatal diethylstilbestrol (DES) exposure are a classic example. Since concern has been mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical with estrogenic activity used in the synthesis of plastics, we investigated its long-term effects in an experimental animal model that was previously shown useful in studying the adverse effects of developmental exposure to DES. Outbred female CD-1 mice were treated on days 1-5 with subcutaneous injections of BPA (10, 100 or 1000 mu g/kg/day) dissolved in corn oil or corn oil alone (Control). At 18 months, ovaries and reproductive tract tissues were examined. There was a statistically significant increase in cystic ovaries and cystic endometrial hyperplasia (CEH) in the BPA-100 group as compared to Controls. Progressive proliferative lesion (PPL) of the oviduct and cystic mesonephric (Wolffian) duct remnants were also seen in all of the BPA groups. More severe pathologies of the uterus following neonatal BPA treatment included adenomyosis, leiomyomas, atypical hyperplasia, and stromal polyps. These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation. Published by Elsevier Inc.