Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives.

Building an apical domain in the early mouse embryo: Lessons, challenges and perspectives.
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DOI:
10.1016/j.ceb.2019.11.005
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发表时间:
2020-02
影响因子:
7.5
通讯作者:
Zernicka-Goetz, Magdalena
Zernicka-Goetz, Magdalena
中科院分区:
生物学2区
文献类型:
--
作者:
Zhu, Meng;Zernicka-Goetz, Magdalena

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在哺乳动物胚胎发生过程中,细胞极化对于谱系分离和形态发生至关重要。然而,在哺乳动物胚胎中建立细胞极性的过程和机制还不清楚。最近的研究表明,独特的调节机制部署的小鼠胚胎建立细胞极化。在这篇综述中,我们讨论了目前对细胞极性建立的理解,重点是在小鼠胚胎顶端域的形成。我们还将讨论悬而未决的问题和未来研究的可能方向。
Cell polarization is critical for lineage segregation and morphogenesis during mammalian embryogenesis. However, the processes and mechanisms that establish cell polarity in the mammalian embryo are not well understood. Recent studies suggest that unique regulatory mechanisms are deployed by the mouse embryo to establish cell polarization. In this review, we discuss the current understanding of cell polarity establishment, focusing on the formation of the apical domain in the mouse embryo. We will also discuss outstanding questions and possible directions for future study.
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