Oxidants and antioxidants affect the expression of glycodelin.
Oxidants and antioxidants affect the expression of glycodelin.
复制标题
氧化剂和抗氧化剂影响甘油磷脂的表达。
DOI：
10.1016/s0891-5849(02)01432-6
复制
发表时间：
2003
影响因子：
7.4
通讯作者：
Parthasarathy,Sampath
中科院分区：
文献类型：
--
作者：
Ramachandran,Sumathi;Rong,Rong;Parthasarathy,Sampath
Glycodelin is a glycoprotein that has immunosuppressive activity. We have shown that K562 cells, hematopoitic progenitor cells, are capable of synthesizing glycodelin peptide (Gp) and, perhaps, contribute to Gp in tissues. In addition, several reproductive and nonreproductive tissues themselves are capable of synthesis of glycodelin. In this study, we report that lipid peroxides induce the synthesis of Gp. Antioxidants vitamin E and pyrrolidine dithiocarbamate (PDTC) and antioxidizing enzymes catalase and superoxide dismutase (SOD) effectively blocked phorbol myristate acetate- (PMA-) and lyso phosphatidic acid- (LPA-) induced synthesis of Gp. Dioctanoin (a mimic of diacylglycerol) activated Gp synthesis, and an inhibitor of protein kinase C (PKC) downregulated the response. Based on these observations, we postulate that oxidants by way of PKC might potentiate the angiogenic process.
