High Th1/Th2 ratio in patients with multiple myeloma
High Th1/Th2 ratio in patients with multiple myeloma
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DOI：
10.1016/j.leukres.2004.06.003
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发表时间：
2005-02-01
影响因子：
2.7
通讯作者：
Murakami, H
中科院分区：
文献类型：
--
作者：
Ogawara, H;Handa, H;Murakami, H
为探讨辅助性T细胞1（Th 1）/辅助性T细胞2（Th 2）比值在多发性骨髓瘤（MM）中的临床意义，采用流式细胞术检测了56例MM患者细胞内IFN-γ和IL-4水平。初治期和难治期患者Th 1/Th 2比值均高于对照组。高Th 1/Th 2亚组血清β 2微球蛋白水平显著高于正常Th 1/Th 2亚组（P < 0.05）。结论：Th 1/Th 2比值与多发性骨髓瘤的病情密切相关。(C)2004 Elsevier Ltd.保留所有权利。
To determine the clinical significance of the T helper 1 (Th1)/T helper 2 (Th2) ratio in multiple myeloma, the intracellular IFN-gamma and IL-4 were analyzed by flow cytometry in 56 patients with Multiple myeloma. The mean Th1/Th2 ratio of cases in the initial diagnosis phase and the refractory phase were higher than that of the control group. The mean serum beta-2-microglobulin in the high Th1/Th2 subgroup was significantly higher than that in the normal Th1/Th2 subgroup (P < 0.05). In conclusion, the Th1/Th2 ratio was closely related to the disease status of multiple myeloma. (C) 2004 Elsevier Ltd. All rights reserved.