Surgical outcomes for gastric cancer of a single institute in southeast China
Surgical outcomes for gastric cancer of a single institute in southeast China
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DOI：
10.1016/j.amjsurg.2010.10.022
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发表时间：
2012-02-01
影响因子：
3
通讯作者：
Xia, Jian-Guo
中科院分区：
文献类型：
--
作者：
Ding, Yong-Bin;Xia, Tian-Song;Xia, Jian-Guo
背景技术背景：近年来，随着社会经济的发展和生活方式的改变，我国东南地区胃癌的发病率以及胃癌患者的手术效果和预后发生了明显的变化。这些患者的临床病理特征和手术结果的趋势进行了回顾性分析。结果：老年人和年轻患者的数量显着增加，在第2期相比，第1期。近端胃肿瘤从20.26%上升到36.83%。早期胃癌的发病率从第1阶段到第2阶段显著增加。淋巴结转移在第2阶段比第1阶段更常见。手术相关的主要并发症发生率从5.23%下降到1.43%。手术死亡率在第1阶段为0.49%，在第2阶段为0.24%。5年生存率从38.40%提高到53.99%。结论：早期诊断、规范的手术治疗（包括有针对性的淋巴结清扫）以及良好的围手术期护理可明显改善胃癌患者的预后。(C)2012 Elsevier Inc. All rights reserved.
BACKGROUND: In recent years, with social and economic development and lifestyle changes, the incidence of gastric cancer as well as the surgical results and prognoses of patients with gastric cancer have changed significantly in southeast China.METHODS: A total of 1,451 patients were divided into 2 groups according to admission time periods. Trends in clinicopathologic characteristics and operative outcomes of these patients were analyzed retrospectively.RESULTS: The numbers of old and young patients were significantly increased in period 2 compared with period 1. Tumors located in the proximal stomach increased from 20.26% to 36.83%. The incidence of early gastric cancer was significantly increased from period 1 to period 2. Lymph node metastasis was seen more prevalently in period 2 than in period 1. The rate of operation-related major complications decreased from 5.23% to 1.43%. Operative mortality was .49% in period 1 and .24% in period 2. The 5-year survival rate increased from 38.40% to 53.99%.CONCLUSIONS: Early diagnosis, standardized surgical treatment including pertinent lymph node dissection, and better perioperative care notably improve the outcomes of patients with gastric cancer. (C) 2012 Elsevier Inc. All rights reserved.