RURAL-POPULATION MIXING AND CHILDHOOD LEUKEMIA - EFFECTS OF THE NORTH-SEA-OIL INDUSTRY IN SCOTLAND, INCLUDING THE AREA NEAR DOUNREAY NUCLEAR SITE
RURAL-POPULATION MIXING AND CHILDHOOD LEUKEMIA - EFFECTS OF THE NORTH-SEA-OIL INDUSTRY IN SCOTLAND, INCLUDING THE AREA NEAR DOUNREAY NUCLEAR SITE
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DOI：
10.1136/bmj.306.6880.743
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发表时间：
1993-03-20
影响因子：
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通讯作者：
MATTHEWS, F
中科院分区：
文献类型：
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作者：
KINLEN, LJ;OBRIEN, F;MATTHEWS, F
目的：确定儿童白血病和非霍奇金淋巴瘤的过量是否与北海石油工业产生的苏格兰农村人口混合的某些显著例子有关。在苏格兰北部设得兰群岛和奥克尼群岛建造大型石油码头或在海上工作的3万多名工人的设计细节被追踪。17160名苏格兰居民的家庭住址进行了邮政编码，与人口普查数据相结合，然后分类为城市或农村。按石油工人比例排序的农村邮政编码地区分为三类，儿童数量相似，但石油工人密度不同。在1974-8年、1979-83年和1984-8年期间，研究了这些农村（以及城市）人群中白血病和非霍奇金淋巴瘤的发病率。研究对象：25岁以下的年轻人。结果：1979- 1983年，在石油工人比例最大的农村家庭地区发现了白血病和非霍奇金淋巴瘤的显著增加，紧随其后的是劳动力的大幅增加。邓雷核设施附近的地区已经是众所周知的白血病发病率过高的地区，属于农村高含油量地区。结论：本研究结果支持了人口混合可增加农村儿童白血病发病率的感染假说。他们还认为，最近在唐尼-瑟索地区的过剩是由于与石油工业有关的人口混合，由某些不寻常的当地人口因素推动。
Objective-To determine if any excess of childhood leukaemia and non-Hodgkin's lymphoma was associated with certain striking examples of population mixing in rural Scotland produced by the North Sea oil industry.Design-Details were traced for over 30 000 workers involved in the construction of the large oil terminals in the Shetland and Orkney islands in northern Scotland or employed offshore. Home addresses of the 17 160 Scottish residents were postcoded, integrated with census data, and then classified as urban or rural. Rural postcode sectors, ranked by proportion of oil workers, were grouped into three categories with similar numbers of children but contrasting densities of oil workers. The incidence of leukaemia and non-Hodgkin's lymphoma was examined in these rural (and also in urban) categories in the periods 1974-8, 1979-83 and 1984-8.Setting-Scotland.Subjects-Young people below age 25.Results-A significant excess of leukaemia and non-Hodgkin's lymphoma was found in 1979-83 in the group of rural home areas with the largest proportion of oil workers, following closely on large increases in the workforce. The area near the Dounreay nuclear installation, where an excess of leukaemia is already well known, was within the rural high oil category.Conclusion-The findings support the infection hypothesis that population mixing can increase the incidence of childhood leukaemia in rural areas. They also suggest that the recent excess in the Dounreay-Thurso area is due to population mixing linked to the oil industry, promoted by certain unusual local demographic factors.