ENERGY-EXPENDITURE IN RATS WITH DIET-INDUCED OBESITY
ENERGY-EXPENDITURE IN RATS WITH DIET-INDUCED OBESITY
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DOI：
10.1093/ajcn/44.2.173
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发表时间：
1986-08-01
影响因子：
7.1
通讯作者：
KEESEY, RE
中科院分区：
文献类型：
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作者：
CORBETT, SW;STERN, JS;KEESEY, RE
研究了高脂肪饮食对体重、肥胖和能量消耗的影响。雄性大鼠分别饲喂8%（对照）或50%脂肪（体重比）6个月。高脂肪组体重增加26%，脂肪细胞大小增加61%，脂肪细胞数量增加48%。然而，食物摄入量和静息耗氧量，虽然绝对数量较高，但都是正常的，因为两者都与大鼠保持的较大体重相称。当通过热量限制减少体重和脂肪细胞大小时，高脂肪组在静息耗氧量方面表现出与对照组相同的适应性调整。我们得出的结论是，长期喂食高脂肪饮食的大鼠1)能量摄入和消耗与它们维持的更大的组织质量和脂肪细胞数量相适应；2)当食物受到限制时，能量消耗表现出适应性的减少，这进一步证明了这种饮食可以改变体重的调节水平。
Effects of a diet high in fat on body weight, adiposity, and energy expenditure were investigated. Male rats were fed 8% (control) or 50% fat (by weight) for 6 mo. The high-fat group increased body weight (+26%), adipocyte size (+61%), and adipocyte number (+48%). However, food intake and resting oxygen consumption, although higher in absolute amount, were normal in that both were commensurate with the greater body mass the rats maintained. When body weight and adipocyte size were reduced by caloric restriction, the high-fat group displayed the same adaptive adjustments in resting oxygen consumption as controls. We conclude that rats fed high-fat diets for prolonged periods 1) have energy intakes and expenditures appropriate for the greater tissue mass and adipocyte number they maintain, and 2) show adaptive reductions in energy expenditure when food is restricted, which provide further evidence that the regulated level of body weight can be altered by such diets.