β-pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes
β-pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes
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DOI：
10.1016/s1383-5718(03)00094-9
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发表时间：
2003-07-08
影响因子：
1.9
通讯作者：
Ando, K
中科院分区：
文献类型：
--
作者：
Monobe, M;Arimoto-Kobayashi, S;Ando, K
我们以前发现，喝啤酒可以减少体外收集和辐射的血液淋巴细胞的染色体畸变。在这项研究中，人全血在体外暴露于200 kVp X射线或50 keV/μ m碳离子在存在或不存在啤酒，乙醇和β-假尿苷（啤酒成分之一）。所有三种药物均减少了由4戈伊X射线或碳离子引起的染色体畸变（双着丝粒）。乙醇、啤酒和β-假尿苷对X射线的最大保护率分别为64%、26%和34%;乙醇、啤酒和β-假尿苷对碳离子的最大保护率分别为22%、26%和32%。它的结论是，β-假尿苷，核苷存在于tRNA，是一种有效的保护剂，对辐射造成的损害，直接和间接的行动。(C)2003年爱思唯尔科学有限公司保留所有权利。
We previously found that drinking beer reduces chromosome aberrations in blood lymphocytes that were collect and irradiated in vitro. In this study, human whole-blood was in vitro exposed to 200 kVp X-rays or 50 keV/mum carbon ions in the presence or absence of beer, ethanol and beta-pseudouridine (one of the beer components). All three agents reduced the chromosome aberrations (dicentric) caused by either X-rays or carbon ions of 4 Gy. The maximum protection for X-rays by ethanol, beer and beta-pseudouridine was 64,26 and 34%, respectively, while the maximum protection for carbon-ion by ethanol, beer and beta-pseudouridine was 22, 26 and 32%, respectively. It is concluded that beta-pseudouridine, a nucleoside present in tRNA, is a potent protector against damage caused by radiation with direct and indirect actions. (C) 2003 Elsevier Science B.V. All fights reserved.