LATE Neuropathologic Changes with Little or No Alzheimer Disease is Common and is Associated with Cognitive Impairment but Not Frontotemporal Dementia.
LATE Neuropathologic Changes with Little or No Alzheimer Disease is Common and is Associated with Cognitive Impairment but Not Frontotemporal Dementia.
复制标题
晚期神经病理学变化很少或没有阿尔茨海默病是常见的，并且与认知障碍相关，但与额颞叶痴呆无关。
DOI：
10.1093/jnen/nlab050
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发表时间：
2021
影响因子：
3.2
通讯作者：
Nelson,PeterT
中科院分区：
文献类型：
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作者：
Nelson,PeterT
边缘主导的年龄相关性TDP-43脑病神经病理学改变（LATE-NC）经常发生在老年大脑中，同时也包含明显的阿尔茨海默病神经病理学改变（ADNC）。关于LATE-NC是否可以独立于ADNC发生的问题已经出现。我们评估了肯塔基大学阿尔茨海默病研究中心尸检队列的数据（包括383名受试者），以解决两个问题：(i)除了患有额颞叶痴呆（FTD）临床综合征的人之外，晚期nc是否在没有ADNC的情况下出现？（ii）在整个ADNC严重程度范围内，LATE-NC是否与认知障碍相关？在本研究中，晚期nc （bbb1期）和低/无ADNC的病理组合是常见的：8.9%（34/383）的所有受试者（包括痴呆和非痴呆个体）表现出这种组合。没有FTLD-TDP病例纳入社区队列。在广泛的ADNC严重程度范围内，LATE-NC的存在与认知功能受损相关，但从未与FTD临床综合征相关。
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) often occur in aged brains that also contain appreciable Alzheimer disease neuropathologic changes (ADNC). Question has arisen as to whether LATE-NC can occur independently of ADNC. We evaluated data from the University of Kentucky Alzheimer’s Disease Research Center autopsy cohort (383 included subjects) to address 2 questions: (i) Is LATE-NC seen in the absence of ADNC, outside of persons who had the frontotemporal dementia (FTD) clinical syndrome? and (ii) is LATE-NC associated with cognitive impairment across the full spectrum of ADNC severity? In the present study, the pathologic combination of LATE-NC (Stage >1) and low/no ADNC was common: 8.9% (34/383) of all subjects (including demented and non-demented individuals) showed this combination. There were no FTLD-TDP cases to be included from the community-based cohort. Across a broad range of ADNC severity, the presence of LATE-NC was associated with impaired cognition but was never associated with a FTD clinical syndrome.