The changing epidemiology of invasive meningococcal disease in Canada, 1985 through 1992. Emergence of a virulent clone of Neisseria meningitidis.
The changing epidemiology of invasive meningococcal disease in Canada, 1985 through 1992. Emergence of a virulent clone of Neisseria meningitidis.
复制标题
1985 年至 1992 年加拿大侵袭性脑膜炎球菌病流行病学的变化。脑膜炎奈瑟菌的强毒克隆的出现。
DOI：
10.1001/jama.1995.03520290042027
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
F. Ashton
中科院分区：
文献类型：
--
作者：
Christine M. Whalen;J. Hockin;A. Ryan;F. Ashton
OBJECTIVE
To describe the occurrence of invasive meningococcal disease (IMD) in Canada with respect to demographic variables and characteristics of the isolated strains of Neisseria meningitidis.
DESIGN
National surveillance case series.
SETTING
Canada, 1985 through 1992.
OUTCOME MEASURES
Morbidity and mortality.
MAIN RESULTS
The incidence of IMD averaged 1.38 per 100,000 person-years, with considerable regional variation. In 1988, serogroup C organisms became more common, with one strain of the electrophoretic type 37 (ET-37) complex of N meningitidis, termed ET-15, the predominant group C strain identified. With the increase in group C disease, a greater proportion of cases were older than 5 years. By 1991, ET-15 was the most common strain identified in most parts of the country. Electrophoretic type 15 had a case fatality of 17.8% vs 8.1% for all other IMD (P < .001). Among cases 20 years and older the case fatality for ET-15 was 22.4%.
CONCLUSIONS
The group C, ET-15 strain of N meningitidis, first identified in Canada, was more virulent than other prevalent strains during this period. Active surveillance, rapid identification, and typing of N meningitidis will assist public health decision making in the control of emerging strains.
年龄对地方性脑膜炎球菌病血清群分布的影响。
影响因子：
8
作者：
Baker,CJ;Griffiss,JM
通讯作者：
Griffiss,JM