Saccadic eye movements are associated with a family history of alcoholism at baseline and after exposure to alcohol
Saccadic eye movements are associated with a family history of alcoholism at baseline and after exposure to alcohol
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DOI：
10.1097/01.alc.0000033121.05006.ef
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发表时间：
2002-10-01
影响因子：
3.2
通讯作者：
O'Connor, S
中科院分区：
文献类型：
--
作者：
Blekher, T;Ramchandani, VA;O'Connor, S
目的：为了评估酒精中毒家族史（FHA）对扫视眼球运动对酒精的反应的影响，方法：在54名健康成人受试者与FHA（家族史阳性）和49名对照（家族史阴性）的扫视性能进行了评估。酒精和安慰剂治疗以平衡顺序呈现。每名受试者静脉注射酒精，以达到并维持目标呼气酒精浓度60 mg/100 ml（60%），持续160 min。在每次会议期间，扫视眼球运动测试进行了基线（酒精输注前）和两次在稳态目标呼吸酒精浓度。扫视测试引起视觉引导扫视（VGS）和反扫视（AS）。扫视的潜伏期和速度和AS错误的百分比进行了量化和分析，采用多变量方差analysis of variances.Results：家族史阳性和家族史阴性组显示在基线AS和VGS潜伏期和速度在酒精和安慰剂会议（p = 0.006）的总体差异。酒精延迟扫视，使AS和VGS潜伏期增加（p = 0.0001），并减慢扫视的执行，使峰值速度降低（p = 0.0002）。酒精给药后AS错误的百分比降低，但未观察到酒精（酒精与安慰剂治疗）的显著影响（p = 0.1）。AS扫视的潜伏期表现出显着的整体FHA效应（p = 0.02）和FHA和响应酒精随着时间的推移（p = 0.02）之间的显着相互作用。结论：扫视控制系统的操作特性的差异与FHA在成人社会饮酒者，无论是在基线和当大脑暴露于乙醇在60毫克/100毫升。
Objective: To evaluate the influence of family history of alcoholism (FHA) on the response of saccadic eye movements to alcohol.Method: Saccadic performance was evaluated in 54 healthy adult subjects with a FHA (family history-positive) and 49 controls (family history-negative). Alcohol and placebo sessions were presented in counterbalanced order. Alcohol was administered intravenously to achieve and maintain a target breath alcohol concentration of 60 mg/100 ml (60%) for 160 min in each subject. During each session, saccadic eye movement testing was performed at baseline (before infusion of alcohol) and twice during the steady-state target breath alcohol concentration. The saccadic testing elicited visually guided saccades (VGS) and antisaccades (AS). Saccadic latency and velocity and the percentage of AS errors were quantified and analyzed using multivariate analysis of variance.Results: The family history-positive and family history-negative groups showed an overall difference at baseline in AS and VGS latencies and velocities in the alcohol and placebo sessions (p = 0.006). Alcohol delayed saccades such that AS and VGS latencies increased (p = 0.0001) and slowed the execution of saccades such that peak velocities decreased (p = 0.0002). The percentage of AS errors decreased after alcohol administration, but no significant effect of alcohol (alcohol versus placebo session) was observed (p = 0.1). Latency of AS saccades demonstrated a significant overall FHA effect (p = 0.02) and a significant interaction between FHA and response to alcohol over time (p = 0.02).Conclusions: Differences in operational characteristics of the saccadic control system are associated with FHA in adult social drinkers, both at baseline and when the brain is exposed to ethanol at 60 mg/100 ml.