Structural covariances of prefrontal subregions selectively associate with dopamine-related gene coexpression and schizophrenia.
Structural covariances of prefrontal subregions selectively associate with dopamine-related gene coexpression and schizophrenia.
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DOI：
10.1093/cercor/bhad096
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发表时间：
2023-03
期刊：
影响因子：
3.7
通讯作者：
Huaigui Liu;Wei Li;Nana Liu;Jie Tang;Lixin Sun;Jiayuan Xu;Yuan Ji;Yingying Xie;Hao Ding;Z. Ye;Chunshui Yu;W. Qin
中科院分区：
文献类型：
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作者：
Huaigui Liu;Wei Li;Nana Liu;Jie Tang;Lixin Sun;Jiayuan Xu;Yuan Ji;Yingying Xie;Hao Ding;Z. Ye;Chunshui Yu;W. Qin
Evidence highlights that dopamine (DA) system dysregulation and prefrontal cortex (PFC) dysfunction may underlie the pathophysiology of schizophrenia. However, the associations among DA genes, PFC morphometry, and schizophrenia have not yet been fully clarified. Based on the brain gene expression dataset from Allen Human Brain Atlas and structural magnetic resonance imaging data (NDIS = 1727, NREP = 408), we first identified 10 out of 22 PFC subregions whose gray matter volume (GMV) covariance profiles were reliably associated with their DA genes coexpression profiles, then four out of the identified 10 PFC subregions demonstrated abnormally increased GMV covariance with the hippocampus, insula, and medial frontal areas in schizophrenia patients (NCASE = 100; NCONTROL = 102). Moreover, based on a schizophrenia postmortem expression dataset, we found that the DA genes coexpression of schizophrenia was significantly reduced between the middle frontal gyrus and hippocampus, in which 21 DA genes showed significantly unsynchronized expression changes, and the 21 genes' brain expression were enriched in brain activity invoked by working memory, reward, speech production, and episodic memory. Our findings indicate the DA genes selectively regulate the structural covariance of PFC subregions by their coexpression profiles, which may underlie the disrupted GMV covariance and impaired cognitive functions in schizophrenia.
