On-chip actuation transmitter for enhancing the dynamic response of cell manipulation using a macro-scale pump
On-chip actuation transmitter for enhancing the dynamic response of cell manipulation using a macro-scale pump
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DOI：
10.1063/1.4907757
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发表时间：
2015-01-01
期刊：
影响因子：
3.2
通讯作者：
Arai, Fumihito
中科院分区：
文献类型：
--
作者：
Monzawa, Takumi;Kaneko, Makoto;Arai, Fumihito
提出了一种实现快速准确细胞操作的片上驱动变送器。采用聚二甲基硅氧烷变形作为介质，传递由泵产生的驱动来控制细胞位置，而不是通过直接连接的宏观泵来操纵细胞位置。这种驱动变送器有三个主要优点。首先，理论建模和实验结果表明，细胞操作的动态响应速度比传统的直接流动控制方法快。电池可以在一个简单的谐波运动高达130赫兹的建议驱动变送器，而不是90赫兹的直接流量控制操作。其次，不需要用样品溶液填充注射泵，因为驱动变送器物理地将泵和细胞流之间的流体分离，因此，只需要非常少量的样品(
An on-chip actuation transmitter for achieving fast and accurate cell manipulation is proposed. Instead of manipulating cell position by a directly connected macro-scale pump, polydimethylsiloxane deformation is used as a medium to transmit the actuation generated from the pump to control the cell position. This actuation transmitter has three main advantages. First, the dynamic response of cell manipulation is faster than the conventional method with direct flow control based on both the theoretical modeling and experimental results. The cell can be manipulated in a simple harmonic motion up to 130 Hz by the proposed actuation transmitter as opposed to 90 Hz by direct flow control. Second, there is no need to fill the syringe pump with the sample solution because the actuation transmitter physically separates the fluids between the pump and the cell flow, and consequently, only a very small quantity of the sample is required (