Comparison of dosimetry between PET/CT and PET alone using 11C-ITMM.
Comparison of dosimetry between PET/CT and PET alone using 11C-ITMM.
复制标题
使用 11C-ITMM 比较 PET/CT 和单独 PET 的剂量测定。
DOI：
10.1007/s13246-015-0419-5
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ishiwata K.
中科院分区：
文献类型：
--
作者：
Ito K;Sakata M;Oda K;Wagatsuma K;Toyohara J;Ishibashi K;Ishii K;Ishiwata K.
我们使用了一种新的示踪剂，N-[4-[6-（异丙基氨基）嘧啶-4-基]-1，3-噻唑-2-基]-4-11 C-甲氧基-N-甲基苯甲酰胺（11 C-ITMM），以比较来自正电子发射断层扫描（PET）/计算机断层扫描（CT）的辐射剂量与先前公布的单独来自PET的剂量。在12次检查中招募了12名健康志愿者[6名男性（平均年龄± SD，27.7 ± 6.7岁）和6名女性（31.8 ± 14.5岁）]。将PET/CT的剂量估计值与单独PET的剂量估计值进行比较。PET/CT中的感兴趣区域（ROI）是根据PET/CT期间采集的低剂量CT（LD-CT）图像描绘的。使用OLINDA/EXM 1.0和CT-Expo软件估计内部和外部辐射剂量。根据PET/CT计算的11 C-ITMM的有效剂量（艾德）估计为4.7 ± 0.5 μSv/MBq（男性受试者）和4.1 ± 0.7 μSv/MBq（女性受试者）。在既往报告中，仅根据PET计算的11 C-ITMM的平均艾德估计为4.6 ± 0.3 μSv/MBq（男性，n = 3）。在男性受试者中，通过PET/CT计算的11 C-ITMM的艾德值与单独PET计算的值几乎相同。从PET/CT计算的胆囊、胃、红骨髓和脾脏的吸收剂量（AD）与仅从PET计算的吸收剂量显著不同。由PET/CT计算的11 C-ITMM的ED与仅由PET计算的ED几乎相同。从PET/CT计算的几个器官中的AD不同于单独从PET计算的AD。在PET/CT期间采集的LD-CT图像可以促进器官识别。
We used a new tracer,N-[4-[6-(isopropylamino) pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-11C-methoxy-N-methylbenzamide (11C-ITMM), to compare radiation doses from positron emission tomography (PET)/computed tomography (CT) with previously published doses from PET alone. Twelve healthy volunteers [six males (mean age ± SD, 27.7 ± 6.7 years) and six females (31.8 ± 14.5 years)] in 12 examinations were recruited. Dose estimations from PET/CT were compared with those from PET alone. Regions of interest (ROIs) in PET/CT were delineated on the basis of low-dose CT (LD-CT) images acquired during PET/CT. Internal and external radiation doses were estimated using OLINDA/EXM 1.0 and CT-Expo software. The effective dose (ED) for11C-ITMM calculated from PET/CT was estimated to be 4.7 ± 0.5 μSv/MBq for the male subjects and 4.1 ± 0.7 μSv/MBq for the female subjects. The mean ED for11C-ITMM calculated from PET alone in a previous report was estimated to be 4.6 ± 0.3 μSv/MBq (males, n = 3). The ED values for11C-ITMM calculated from PET/CT in the male subjects were almost identical to those from PET alone. The absorbed doses (ADs) of the gallbladder, stomach, red bone marrow, and spleen calculated from PET/CT were significantly different from those calculated from PET alone. The EDs of11C-ITMM calculated from PET/CT were almost identical to those calculated from PET alone. The ADs in several organs calculated from PET/CT differed from those from PET alone. LD-CT images acquired during PET/CT may facilitate organ identification.