Cellular senescence and the aging brain
Cellular senescence and the aging brain
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DOI：
10.1016/j.exger.2014.09.018
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发表时间：
2015-08-01
影响因子：
3.9
通讯作者：
Andersen, Julie K.
中科院分区：
文献类型：
--
作者：
Chinta, Shankar J.;Woods, Georgia;Andersen, Julie K.
细胞衰老是一种有效的抗癌机制，它可以阻止有丝分裂能力细胞的增殖，从而防止恶性转化。随着年龄的增长，衰老细胞在各种人类和小鼠组织中积累，在那里它们表达复杂的“衰老相关分泌表型”（SASP）。SASP包括许多促炎细胞因子、趋化因子、生长因子和蛋白酶，它们有可能导致或加剧与年龄相关的病理，包括退行性和增生性。虽然外周组织的细胞衰老最近与许多与年龄相关的病理联系在一起，但它与大脑衰老的关系才刚刚开始被探索。最近由几个实验室产生的数据表明，衰老和与年龄相关的神经退行性疾病都伴随着大脑中非神经元来源的表达sasp的衰老细胞的增加。此外，这种增加与神经退行性变有关。因此，大脑中的衰老细胞可能构成治疗与年龄相关的神经病变的新治疗靶点。(C) 2014爱思唯尔公司版权所有。
Cellular senescence is a potent anti-cancermechanismthat arrests the proliferation of mitotically competent cells to prevent malignant transformation. Senescent cells accumulate with age in a variety of human and mouse tissues where they express a complex 'senescence-associated secretory phenotype' (SASP). The SASP includes many pro-inflammatory cytokines, chemokines, growth factors and proteases that have the potential to cause or exacerbate age-related pathology, both degenerative and hyperplastic. While cellular senescence in peripheral tissues has recently been linked to a number of age-related pathologies, its involvement in brain aging is just beginning to be explored. Recent data generated by several laboratories suggest that both aging and age-related neurodegenerative diseases are accompanied by an increase in SASP-expressing senescent cells of nonneuronal origin in the brain. Moreover, this increase correlates with neurodegeneration. Senescent cells in the brain could therefore constitute novel therapeutic targets for treating age-related neuropathologies. (C) 2014 Elsevier Inc. All rights reserved.