P-GLYCOPROTEIN IN ADULT SOLID TUMORS - EXPRESSION AND PROGNOSTIC-SIGNIFICANCE
P-GLYCOPROTEIN IN ADULT SOLID TUMORS - EXPRESSION AND PROGNOSTIC-SIGNIFICANCE
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DOI：
10.1016/s0889-8588(18)30095-9
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发表时间：
1995-04-01
影响因子：
2.4
通讯作者：
GOLDSTEIN, LJ
中科院分区：
文献类型：
--
作者：
LEIGHTON, JC;GOLDSTEIN, LJ
在成人实体瘤中已经确定了几种潜在的化疗耐药机制。多药耐药（MDR）表型是肿瘤可能同时对多种化疗药物产生耐药性的一种机制，并与 P-糖蛋白表达相关。在本文中，作者查阅了文献并总结了用于测量 MDR1 基因表达以及成人实体瘤中表达模式的各种技术。
Several potential mechanisms of chemotherapy resistance have been identified in adult solid tumors. The multidrug resistance (MDR) phenotype is one mechanism by which tumors may simultaneously develop resistance to multiple chemotherapeutic agents and is associated with P-glycoprotein expression. Ln this article, the authors examine the literature and summarize the various techniques used to measure MDR1 gene expression, patterns of expression in adult solid tumors.