Cancer and heterogeneity of obesity: a potential contribution of brown fat
Cancer and heterogeneity of obesity: a potential contribution of brown fat
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DOI：
10.2217/fon.12.150
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发表时间：
2012-12-01
期刊：
影响因子：
3.3
通讯作者：
Berstein, Lev M.
中科院分区：
文献类型：
--
作者：
Berstein, Lev M.
最近，肥胖作为一种潜在的癌症风险引起了更多的关注，除了一些例外，它也是一种预后因素。由于肥胖是一个复杂的问题，其特点是不同的变体，机制和表现，它在癌症发展中的作用也是一个复杂的问题，超出了脂肪含量上升到一定限度以上的基本事实。因此，在本论文中，肥胖被视为一个异质实体，它与癌症的发病机制有着独特的联系。在其他问题中，重点是白色和棕色脂肪组织的状态，特别是特定的棕色脂肪特征和所谓的白色脂肪布朗宁与正常和突变的肿瘤抑制基因，如PTEN和BRCA 1的功能的关联。这些联系被认为是从暗示存在两种类型的激素致癌作用和激素介导的遗传易感性肿瘤发展的观点，并应占在预防和治疗肥胖和癌症。
Obesity has lately been drawing additional attention as a potential cancer risk and, with some exceptions as a prognostic factor. As obesity is a complex issue characterized by different variants, mechanisms and manifestations, its role in cancer development is also a complex problem exceeding the basic fact of the fat content rising above certain limits. Therefore, in the present paper obesity is viewed as a heterogeneous entity, which has distinct connections with cancer pathogenesis. Among other issues, emphasis is made on the state of white and brown adipose tissue, in particular the association of specific brown fat features and the so-called white fat browning with the functions of normal and mutated tumor suppressor genes, such as PTEN and BRCA1. These connections are considered from the viewpoint implying the existence of two types of hormonal carcinogenesis and of hormonal mediation of the genetic predisposition to tumor development, and should be accounted for in prevention and treatment of both obesity and cancer.