Intestinal gluconeogenesis: key signal of central control of energy and glucose homeostasis
Intestinal gluconeogenesis: key signal of central control of energy and glucose homeostasis
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DOI：
10.1097/mco.0b013e32832c4d6a
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发表时间：
2009-07-01
影响因子：
3.1
通讯作者：
Magnan, Christophe
中科院分区：
文献类型：
--
作者：
Mithieux, Gilles;Andreelli, Fabrizio;Magnan, Christophe
综述的目的已经确定，肠道不仅仅是消化道。它有能力通过分泌各种激素参与能量稳态的控制。它还可以通过其高血糖水平来控制葡萄糖稳态。最近的发现除了其在内源性葡萄糖产生中的定量作用外，最近还描述了其在肠内葡萄糖生成中的定性作用（即中枢信号传导）。关于能量稳态的控制，肠内异生，通过肝门静脉葡萄糖传感器的检测，能够产生控制食物摄入的中枢信号，导致增强的饱腹感。这种机制已被认为是众所周知的由食物蛋白质引发的饱腹感效应的原因。与葡萄糖稳态的控制有关，肠道胰岛素生成被认为是全身胰岛素敏感性中枢增强的关键因素。它可能特别是占快速改善后发生的参数的胰岛素抵抗胃旁路，一个特定类型的手术obesity.SummaryThese新的发现肠erytheogenesis的作用，在中央控制的能量和葡萄糖稳态应该是营养学家和糖尿病学家的兴趣。它们为设想预防或治疗人类肥胖和2型糖尿病的新策略铺平了道路。
Purpose of reviewIt has been established that the gut is much more than a digestive tract. It has the capacity to participate in the control of energy homeostasis via the secretion of various hormones. It can also contribute to the control of glucose homeostasis via its high. glycolytic capacity and a recently described function, gluconeogenesis.Recent findingsIn addition to its quantitative role in endogenous glucose production, qualitative roles (i.e. central signaling) were recently described for intestinal gluconeogenesis. In relation to the control of energy homeostasis, intestinal gluconeogenesis, via its detection by a hepatoportal glucose sensor, is able to generate a central signal of control of food intake, resulting in enhanced satiety. This mechanism has been suggested to account for the well known satiety effect initiated by food protein. In relation to the control of glucose homeostasis, intestinal gluconeogenesis has been suggested to be a key factor of the central enhancement of insulin sensitivity for the whole body. It may especially account for the rapid amelioration of the parameters of insulin resistance occurring after gastric bypass, a specific type of surgery of obesity.SummaryThese new findings on the role of intestinal gluconeogenesis in the central control of energy and glucose homeostasis should be of interest for nutritionists and diabetologists. They pave the way to envision new strategies of prevention or treatment of obesity and type 2 diabetes in humans.