Characterization of nociceptive behavioural responses in the awake pig following UV-B-induced inflammation
Characterization of nociceptive behavioural responses in the awake pig following UV-B-induced inflammation
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DOI：
10.1002/j.1532-2149.2013.00340.x
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发表时间：
2014-01-01
影响因子：
3.6
通讯作者：
Herskin, M. S.
中科院分区：
文献类型：
--
作者：
Di Giminiani, P.;Petersen, L. J.;Herskin, M. S.
背景在目前的平移性炎性痛模型中，紫外线（UV）照射引起了人们越来越多的兴趣。原发性热和机械性痛觉过敏的发展已在人类和啮齿动物中观察到。方法用1J/cm（2）的UV-B光源照射清醒的猪的侧腹部皮肤，观察其在不同时间点的变化。结果照射后24 h，炎症部位的热敏感性显著增加，从基线到24小时，对热刺激反应的潜伏期减少（P
BackgroundAmong the current translational inflammatory pain models, the ultraviolet (UV) irradiation is of rapidly growing interest. The development of primary thermal and mechanical hyperalgesia has been observed in humans and rodents. The pig as a translational animal model might be advantageous due to its great homology with humans.MethodsThe skin in the flank of awake pigs was irradiated by a UV-B light source (1J/cm(2)) and changes in thermal and mechanical sensitivity 24 and 48h following irradiation were measured via assessment of nociceptive behaviours.ResultsThermal sensitivity increased significantly within the inflamed site 24h after irradiation as indicated by the reduction of latency to respond to thermal stimulation from baseline to 24h (P