A Diamond-Based Electrode for Detection of Neurochemicals in the Human Brain.
A Diamond-Based Electrode for Detection of Neurochemicals in the Human Brain.
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DOI：
10.3389/fnhum.2016.00102
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发表时间：
2016
影响因子：
2.9
通讯作者：
Lee KH
中科院分区：
文献类型：
--
作者：
Bennet KE;Tomshine JR;Min HK;Manciu FS;Marsh MP;Paek SB;Settell ML;Nicolai EN;Blaha CD;Kouzani AZ;Chang SY;Lee KH
脑深部电刺激（DBS）是一种治疗某些神经和精神疾病的手术技术，依赖于开环配置中的预定刺激参数。DBS器械的主要进步是使用神经生理反馈动态调整刺激频率和振幅的闭环系统。刺激驱动的神经化学释放可以通过快速扫描循环伏安法（FSCV）测量，但现有的FSCV电极依赖于碳纤维，其在使用过程中迅速降解，因此不适合慢性神经化学记录。为了解决这个问题，我们开发了耐用的合成硼掺杂金刚石电极，能够测量人体神经化学物质的释放。与碳纤维电极相比，它们的物理耐用性高出两个数量级以上，并且在体外寿命长而不变质。首次应用于人类，从接受DBS治疗震颤的患者（n = 4）的丘脑靶的金刚石电极记录产生了与腺苷释放一致的信号，其灵敏度与碳纤维电极相当。（临床试验编号NCT01705301）。
Deep brain stimulation (DBS), a surgical technique to treat certain neurologic and psychiatric conditions, relies on pre-determined stimulation parameters in an open-loop configuration. The major advancement in DBS devices is a closed-loop system that uses neurophysiologic feedback to dynamically adjust stimulation frequency and amplitude. Stimulation-driven neurochemical release can be measured by fast-scan cyclic voltammetry (FSCV), but existing FSCV electrodes rely on carbon fiber, which degrades quickly during use and is therefore unsuitable for chronic neurochemical recording. To address this issue, we developed durable, synthetic boron-doped diamond-based electrodes capable of measuring neurochemical release in humans. Compared to carbon fiber electrodes, they were more than two orders-of-magnitude more physically-robust and demonstrated longevity in vitro without deterioration. Applied for the first time in humans, diamond electrode recordings from thalamic targets in patients (n = 4) undergoing DBS for tremor produced signals consistent with adenosine release at a sensitivity comparable to carbon fiber electrodes. (Clinical trials # NCT01705301).