The presence of 4‐hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach
The presence of 4‐hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach
复制标题
人唾液中4-羟基苯乙酸的存在及其在胃中被唾液亚硝酸盐硝化的可能性
DOI：
10.1016/s0014-5793(02)02659-5
复制
发表时间：
2002
期刊：
影响因子：
3.5
通讯作者：
H. Murata
中科院分区：
文献类型：
--
作者：
U. Takahama;T. Oniki;H. Murata
人唾液中含有4-羟基苯乙酸(2-10μM)和亚硝酸盐(60-300μM)。当HPA和亚硝酸钠在pH 1.0下混合时，HPA被硝化为4-羟基-3-硝基苯乙酸(NO2HPA)。当唾液在酸性条件下孵育时，也会形成NO2HPA。这些结果表明，当唾液被吞入胃中时，唾液HPA被硝化为NO2HPA。
Human saliva contained 4-hydroxyphenylacetic acid (HPA) (2–10 μM) and nitrite (60–300 μM). HPA was nitrated to 4-hydroxy-3-nitrophenylacetic acid (NO2HPA) when HPA and sodium nitrite were mixed at pH 1.0. NO2HPA was also formed when saliva was incubated under acidic conditions. These results suggest that salivary HPA is nitrated to NO2HPA when saliva is swallowed into the stomach.