The fly Drosophila subobscura:: A natural case of innate immunity deficiency
The fly Drosophila subobscura:: A natural case of innate immunity deficiency
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DOI：
10.1016/j.dci.2006.02.007
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发表时间：
2006-01-01
影响因子：
2.9
通讯作者：
Doury, Geraldine
中科院分区：
文献类型：
--
作者：
Eslin, Patrice;Doury, Geraldine
研究人员发现，果蝇幼虫无法在寄生卵或惰性异物周围形成胶囊。本文还探讨了这种失能的特异性和生理原因：循环血细胞分析表明，D.幼虫寄主。因此，果蝇D. subobscura是第一个被发现的对多种寄生虫呈现先天免疫缺陷的动物物种。这与认为所有生物体在自然条件下都有可能保护自己免受寄生的理论相反。这一意外的发现开启了关于免疫抵抗的代价的进化论辩论，不仅在种群水平上，而且在整个物种的水平上。我们相信这种果蝇可以成为研究造血相关基因的新模型系统，并在更大的背景下更好地了解生物体的防御反应。(c)2006爱思唯尔有限公司保留所有权利。
The Drosophila subobscura larvae were found to be unable to form a capsule around a parasitic egg or an inert foreign body. The specificity and physiological causes of this incapacity were also explored: analysis of the circulating hemocytes showed that no lamellocyte was ever found in D. subobscura host larvae. Therefore, the fly D. subobscura is the first discovered animal species to present an innate immunodeficiency against a wide range of parasites. This is contrary to the theories that propose that all organisms, in natural conditions, are potentially able to defend themselves against parasitization. This unexpected finding opens evolutionary debates about the cost of immune resistance not only at the level of a population, but also of a whole species. We believe this species of fruitfly could become a new model system to study genes involved in hematopoiesis, and in a larger context to better understand defence reactions in organisms. (c) 2006 Elsevier Ltd. All rights reserved.