A FAMILY OF SACCHAROMYCES-CEREVISIAE REPETITIVE AUTONOMOUSLY REPLICATING SEQUENCES THAT HAVE VERY SIMILAR GENOMIC ENVIRONMENTS
A FAMILY OF SACCHAROMYCES-CEREVISIAE REPETITIVE AUTONOMOUSLY REPLICATING SEQUENCES THAT HAVE VERY SIMILAR GENOMIC ENVIRONMENTS
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DOI：
10.1016/s0022-2836(83)80299-x
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发表时间：
1983-01-01
影响因子：
5.6
通讯作者：
TYE, BK
中科院分区：
文献类型：
--
作者：
CHAN, CSM;TYE, BK
在S.描述了酿酒酵母。限制性酶切图谱、缺失研究和杂交研究表明，这些ARS的大小可能小于350个碱基对，具有一个共同的功能：每个ARS都位于. apprx的重复序列（131）附近，但不在其内。103至. apprx。1.5. times.长度为103个碱基对这些ARS根据其序列同源性和基因组环境可分为两类（X和Y）。每个X类ARS嵌入可变长度（. apprx）的重复序列（X）中。0.3. times. 103至. apprx。3.75. times. 103个碱基对）;每个Y类ARS嵌入在高度保守的重复序列（Y）中。5.2. times.长度为103个碱基对这两个序列都直接位于131序列附近。
A family of moderately repetitive autonomously replicating sequences (ARS) in S. cerevisiae is described. Restriction mapping, deletion studies and hybridization studies suggest that these ARS, which are probably < 350 base-pairs in size, share 1 common feature: each is located close to, but not within, a repetitive sequence (131) of .apprx. 103 to .apprx. 1.5 .times. 103 base pairs in length. These ARS can be divided into 2 classes (X and Y) by their sequence homology and genomic environments. Each of the class X ARS is embedded within a repetitive sequence (X) of variable length (.apprx. 0.3 .times. 103 to .apprx. 3.75 .times. 103 base pairs); each of the class Y ARS is embedded within a highly conserved repetitive sequence (Y) of .apprx. 5.2 .times. 103 base pairs in length. Both of these sequences are located directly adjacent to the 131 sequence.