Mathematical model in post-mortem estimation of brain edema using morphometric parameters.
Mathematical model in post-mortem estimation of brain edema using morphometric parameters.
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使用形态测量参数进行死后脑水肿估计的数学模型。
DOI：
10.1016/j.jflm.2016.11.006
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发表时间：
2017
影响因子：
1.5
通讯作者：
Savic,Slobodan
中科院分区：
文献类型：
--
作者：
Radojevic,Nemanja;Radnic,Bojana;Vucinic,Jelena;Cukic,Dragana;Lazovic,Ranko;Asanin,Bogdan;Savic,Slobodan
目前评估脑水肿是否存在的尸检原则是基于病理学家进行的宏观主观评估。金标准是对水肿存在进行耗时的组织学验证。通过测量颅腔的直径，作为单独确定的形态测量参数，根据尸检期间测量的脑重量，创建了快速评估脑水肿的数学模型。对 110 名受试者进行了一项队列研究，根据组织学上是否存在（从文本中删除）脑水肿将其分为两组。在所有受试者中，确定以下测量值：颅腔的体积和直径（纵向和横向距离和高度）、脑体积和脑重量。复杂的数学算法揭示了系数 ε 的公式，可用于推断是否存在脑水肿。非水肿脑的平均密度为0.967 g/ml，而水肿脑的平均密度为1.148 g/ml。系数 ε 的计算公式为（5.79 x 纵向距离 x 横向距离）/脑重量。系数 ε 可以通过尸检期间测量的颅腔直径和脑重量来计算。如果所得的ε小于0.9484，则可以判定存在脑水肿，可靠性为98.5%。本文讨论的方法旨在消除在确定是否存在脑水肿时依赖主观评估的负担。
Current autopsy principles for evaluating the existence of brain edema are based on a macroscopic subjective assessment performed by pathologists. The gold standard is a time-consuming histological verification of the presence of the edema. By measuring the diameters of the cranial cavity, as individually determined morphometric parameters, a mathematical model for rapid evaluation of brain edema was created, based on the brain weight measured during the autopsy. A cohort study was performed on 110 subjects, divided into two groups according to the histological presence or absence of (the – deleted from the text) brain edema. In all subjects, the following measures were determined: the volume and the diameters of the cranial cavity (longitudinal and transverse distance and height), the brain volume, and the brain weight. The complex mathematical algorithm revealed a formula for the coefficient ε, which is useful to conclude whether a brain edema is present or not. The average density of non-edematous brain is 0.967 g/ml, while the average density of edematous brain is 1.148 g/ml. The resulting formula for the coefficient ε is (5.79 x longitudinal distance x transverse distance)/brain weight. Coefficient ε can be calculated using measurements of the diameters of the cranial cavity and the brain weight, performed during the autopsy. If the resulting ε is less than 0.9484, it could be stated that there is cerebral edema with a reliability of 98.5%. The method discussed in this paper aims to eliminate the burden of relying on subjective assessments when determining the presence of a brain edema.
影响因子：
2.2
作者：
G. Quatrehomme;J. Ponsaillé;P. Jardin;Céline Leccia;V. Alunni
通讯作者：
V. Alunni
影响因子：
4.1
作者：
KIMELBERG, HK
通讯作者：
KIMELBERG, HK