GENEVESTIGATOR. Arabidopsis microarray database and analysis toolbox
GENEVESTIGATOR. Arabidopsis microarray database and analysis toolbox
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DOI：
10.1104/pp.104.046367
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发表时间：
2004-09-01
期刊：
影响因子：
7.4
通讯作者：
Gruissem, W
中科院分区：
文献类型：
--
作者：
Zimmermann, P;Hirsch-Hoffmann, M;Gruissem, W
高通量基因表达分析已成为生物学中常用而有力的研究工具。然而，目前很少有软件应用程序已经开发出来，供生物学家使用web浏览器界面查询大型微阵列基因表达数据库。我们提出genevetiator，一个数据库和web浏览器数据挖掘接口，用于Affymetrix基因芯片数据。用户可以查询数据库以检索在选定的环境条件、生长阶段或器官中单个基因的表达模式。相反，挖掘工具允许用户识别在选定的压力、生长阶段或特定器官中特异性表达的基因。使用genevetiator，可以获得超过22,000个拟南芥基因的基因表达谱，包括10,600个目前尚未表征的基因。该软件应用程序的目的是通过为植物生物学家提供有关基因表达的上下文信息来指导基因功能的发现和新实验的设计。数据库和分析工具箱作为社区资源可在https://www.genevestigator.ethz.ch上获得。
High-throughput gene expression analysis has become a frequent and powerful research tool in biology. At present, however, few software applications have been developed for biologists to query large microarray gene expression databases using a Web-browser interface. We present GENEVESTIGATOR, a database and Web-browser data mining interface for Affymetrix GeneChip data. Users can query the database to retrieve the expression patterns of individual genes throughout chosen environmental conditions, growth stages, or organs. Reversely, mining tools allow users to identify genes specifically expressed during selected stresses, growth stages, or in particular organs. Using GENEVESTIGATOR, the gene expression profiles of more than 22,000 Arabidopsis genes can be obtained, including those of 10,600 currently uncharacterized genes. The objective of this software application is to direct gene functional discovery and design of new experiments by providing plant biologists with contextual information on the expression of genes. The database and analysis toolbox is available as a community resource at https://www.genevestigator.ethz.ch.