Effects of particulate air pollution on asthmatics.
Effects of particulate air pollution on asthmatics.
复制标题
颗粒空气污染对哮喘患者的影响。
DOI：
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发表时间：
1983
影响因子：
12.7
通讯作者：
P. Weiser
中科院分区：
文献类型：
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作者：
G. Perry;H. Chai;D. Dickey;R. H. Jones;R. Kinsman;C. G. Morrill;S. Spector;P. Weiser
从1979年1月到3月，对丹佛市24名哮喘患者进行了跟踪调查。在这三个月的时间里，丹佛市的空气污染水平普遍很高，而且变化很大。二分法、虚拟撞击式采样器提供了吸入颗粒物（总质量、硫酸盐和硝酸盐）的每日测量值（微克/立方米），包括粗颗粒（空气动力学直径2.5- 15微克）和细颗粒（小于2.5微米）。还测量了一氧化碳、二氧化硫、臭氧、温度和气压。每天两次测量每个受试者的呼气流速峰值，按需使用雾化支气管扩张剂，并报告哮喘特有的气道阻塞症状，使用随机效应模型测试与空气污染物的关系。在实际观察的时间里，记录到高浓度悬浮微粒的日子很少。在研究的环境变量中，只有细硝酸盐与症状报告增加和雾化支气管扩张剂使用增加有关。
Twenty-four asthmatic subjects in Denver were followed from January through March 1979, a three-month period in which Denver air pollution levels are generally high and variable. Dichotomous, virtual impactor samplers provided daily measurements (micrograms/m3) of inhaled particulate matter (total mass, sulfates, and nitrates) for coarse (2.5--15 micrograms in aerodynamic diameter) and fine fractions (less than 2.5 micrometers). Carbon monoxide, sulfur dioxide, ozone, temperature, and barometric pressure were also measured. Twice daily measurements of each subject's peak expiratory flow rates, use of as-needed aerosolized bronchodilators, and report of airways obstruction symptoms characteristic of asthma were tested for relationships to air pollutants using a random effects model across subjects. During the time actually observed, there were very few days in which high levels of suspended particulates were recorded. Of the environmental variables studied, only fine nitrates were associated with increased symptom reports and increased aerosolized bronchodilator usage.