Progenitor Cells of the Mandibular Condylar Cartilage.
Progenitor Cells of the Mandibular Condylar Cartilage.
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下颌髁软骨祖细胞。
DOI：
10.1007/s40610-015-0019-x
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Wadhwa,Sunil
中科院分区：
文献类型：
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作者：
Robinson,Jennifer;O'Brien,Alina;Chen,Jing;Wadhwa,Sunil
下颌骨髁状突的次级软骨是独特的，因为它在生长过程中经历软骨内骨化，并响应于其机械载荷环境的变化而进行稳健的重塑。这种软骨来源于表达早期成骨细胞分化标志物的间充质祖细胞，即碱性磷酸酶（ALP）和Runx相关转录因子2（Runx 2）。有趣的是，这些祖细胞然后在适当的机械负荷下分化成软骨。我们的实验室已经确定，这些细胞可以标记成骨祖细胞标记，包括大鼠1型胶原蛋白的3.6片段。然而，这些间充质祖细胞在成人下颌髁突软骨维持和适应中的作用，以及下颌髁突软骨内更有效的祖细胞群的存在，仍然存在疑问。这些细胞的进一步表征是必要的，以确定其效力和再生能力，阐明其再生治疗的潜力。
The secondary cartilage of the mandibular condyle is unique as it undergoes endochondral ossification during growth and robustly remodels in response to changes in its mechanical loading environment. This cartilage is derived from mesenchymal progenitor cells that express markers of early osteoblast differentiation, namely alkaline phosphatase (ALP) and runt-related transcription factor 2 (Runx2). Interestingly, these progenitor cells then differentiate into cartilage with appropriate mechanical loading. Our laboratory has determined that these cells can be labeled by osteoblast progenitor cell markers, including the 3.6 fragment of the rat collagen type 1. However, the role these mesenchymal progenitor cells play in adult mandibular condylar cartilage maintenance and adaptation, as well as the existence of a more potent progenitor cell population within the mandibular condylar cartilage, remains in question. Further characterization of these cells is necessary to determine their potency and regenerative capacity to elucidate their potential for regenerative therapy.