OCTREOTIDE AND GRAVES OPHTHALMOPATHY AND PRETIBIAL MYXEDEMA
OCTREOTIDE AND GRAVES OPHTHALMOPATHY AND PRETIBIAL MYXEDEMA
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DOI：
10.1136/bmj.304.6820.158
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发表时间：
1992-01-18
影响因子：
--
通讯作者：
HUANG, KM
中科院分区：
文献类型：
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作者：
CHANG, TC;KAO, SCS;HUANG, KM
中华民国台湾地区甲状腺切除术后对IGF-1和胫骨前粘液性水肿的反应三TC常，医学博士，教授的治疗月与奥曲肽100 [tg每日三次intermedicine胫骨前粘液水肿。2奥曲肽，一种有效的长效药物，减少了她的外斜视（表）和她的皮肤SCS Kao，MD，辅助生长抑素类似物，3抑制IGF-1活性的变化。在停止眼科教授治疗后一个月，通过间接降低治疗KM Huang，MD，相关生长激素的血浆浓度或直接阻断眼科教授IGF-1对外周组织的作用，患者病情稳定。4.根据Graves评分标准，报告奥曲肽治疗6例患者的疗效。此外，在患有眼病的患者中，其中三名患者还接受了胫前奥曲肽治疗，这可能会抑制粘液水肿引起的IGF-1的局部合成。炎症或通过受体后抑制4和BMJ 1992; 304：158，从而抑制纤维糖胺聚糖的合成-病例报告眼眶和皮肤中的胚细胞。控制溢泪可能与抑制外分泌有关。病例IA，27岁，患有甲状腺毒症的女性，用甲巯咪唑治疗后瘙痒和红斑迅速改善。她开发可能表明抑制释放炎性进行性眼球突出，复视，眼睛疼痛，介质。我们的经验表明，奥曲肽与溢泪。奥曲肽100 μ g/日对照治疗对Graves眼病和两天后溢泪有效，一周后疼痛有效。胫前粘液性水肿，并与小侧有关。三周后，她的复视开始改善。她的效果：第一周的轻度腹部不适在三个月的治疗后保持稳定，注射部位疼痛。额外的人（-一个四onh跟进。需要进行研究以确定确切的机制C1 ase 2-一名患有奥曲肽的Graves眼病的58岁妇女。运动病和胫骨前粘液性水肿用奥曲肽100 μ g每天治疗三次。她的症状，我们感谢山德士制药公司提供的，包括粘液水肿解决四周后，奥曲肽，和博士R Teoh为他的帮助.服用奥曲肽三个月后，她仍然很好（表）。I Hansson HA，Petruson B，Skottner A.生长调节素C在病例3发病机制中的作用-一名37岁男性发生内分泌源性恶性突眼恶化。Lancet 1986; i：218-9.眼球突出和所有注视方向的复视2 Kriss JP。胫前粘液水肿的发病机制及治疗。内分泌代谢临床北美1987; 16：409-15。甲状腺切除术后他服用奥曲肽100 [IG 3 BauerW，BrinerU，Doepfner W，HallerR，HugueninR，马尔巴赫P，埃塔尔每天短信三次，持续三个月，取得了一些改善201-995：一种非常有效且选择性的八肽类似物，可用于治疗抑郁症（表）。延长作用时间无变化。生命科学1982; 31：1133-40.在他的复视右凝视（表）。没有变化是4 Tsuzaki 5，摩西AC。生长抑素抑制脱氧核糖核酸的合成后，随访两个月。在FRTL-5中由促甲状腺激素和胰岛素样生长因子-I诱导的病例4-一名50岁的妇女，以前接受过细胞内分泌学治疗1990; 126：3131-8。甲状腺切除术和放射性碘在-之前开发（1991年7月30日接受）
Taiwan, Republic of China reactivity alin litkegrowth factor-(IGF-1) s and pretibial myxoedema after a thyroidectomy. Three TC Chang, MD, professor of months' treatment with octreotide 100 [tg thrice daily interalmedicine pretibial myxoedema. 2 Octreotide, a potentlong acting reduced her exopthalmos (table) and her skin SCS Kao, MD, assistant somatostatin analogue, 3 suppresses IGF-1 actiVity changes. Sheremainedstableonemonthafterstopping professor ofophthalmology either indirectly, by reducing plasma concentrations of treatment KM Huang, MD, associate growth hormone or directly, by blocking the effect of professor ofradiology IGF-1 on peripheral tissue. 4 We report the therapeutic effect of octreotide in six patients with Graves' Comment ProfessorChang. ophthalmopathy, three of whom also had pretibial Octreotide may inhibit local synthesis of IGF-l from myxoedema. inflammation or through postreceptor inhibition4 and BMJ 1992; 304: 158 thereby inhibit glycosaminoglycan synthesis by fibro-Case reports blasts in the orbit and skin. Control of epiphora is probably related to inhibition of exocrine secretion Case IA 27 year old woman with thyrotoxicosis whereas rapid improvement in itching and erythema had been treated with methimazole. She developed may indicate inhibition of release of inflammatory progressive exophthalmos, diplopia, and sore eyes, mediators. Our experience suggests that octreotide with epiphora. Octreotide 100 [igthrice daily controlled treatment is effective in Graves' ophthalmopathy and the epiphora after two days and soreness after a week. pretibial myxoedema and is associated with minor side Her diplopia began to improve after three weeks. Her effects: mild abdominal discomfort in the first week of condition remained stable after three months' treat-treatment and pain at the injection site. Additional men (-A four onh follow up. studies are required to ascertain the exact mechanism C, ase 2-A 58 year old woman with Graves' opthal-ofaction of octreotide. mopathy and pretibial myxoedema was treated with octreotide 100 jig thrice daily. Her symptoms, We thank Sandoz Pharmaceuticals for supplying the including the myxoedema resolved after four weeks, octreotide, and Dr R Teoh for his help. and she remained well three months after taking octreotide for three months (table). I Hansson HA, Petruson B, Skottner A. Somatomedin C in pathogenesis of Case 3-A 37 year old man developed worsening malignant exophthalmosof endocrine origin. Lancet 1986; i: 218-9. exophthalmos and diplopia in all directions of gaze 2 Kriss JP. Pathogenesis and treatment of pretibial myxedema. EndocrinolMetab Clin North Am 1987; 16: 409-15. after a thyroidectomy. He took octreotide 100 [ig 3 BauerW, BrinerU, Doepfner W, HallerR, HugueninR, Marbach P, etal. SMS thrice daily for three months with some improvement 201-995: a very potent and selective octapeptide analogue of somatostatin inhisdiplopaon right gae (table). Nochange was~ with prolonged action. LifeSci 1982; 31: 1133-40. in his diplopia on right gaze (table). No change was 4 Tsuzaki 5, Moses AC. Somatostatin inhibits deoxyribonucleic acid synthesis observed after follow up for two months. induced by both thyrotropin and insulin-like growth factor-I in FRTL-5 Case 4-A 50 year old woman previously treated by cells Endocrinology1990; 126: 3131-8. thyroidectomy and radioacitive iodine developed pre-(Accepted30July 1991)