Natural products against HIV latency
Natural products against HIV latency
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DOI：
10.1097/hm9.0000000000000004
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发表时间：
2021-09
期刊：
影响因子：
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通讯作者：
Kouharu Otsuki;Mi Zhang;Wei Li
中科院分区：
文献类型：
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作者：
Kouharu Otsuki;Mi Zhang;Wei Li
抗逆转录病毒治疗在抑制人类免疫缺陷病毒（HIV）复制和将HIV感染从致命疾病转变为可控制的慢性疾病方面取得了巨大成功。然而，潜伏的HIV病毒库在HIV感染者体内持续存在，并且容易重新激活。因此，需要开发新的治疗方法，以彻底治愈艾滋病毒。根除艾滋病毒的主要战略是通过一种称为“休克和杀伤”的方法消除和防止潜伏库的重新激活。这种策略包括使用潜伏逆转剂（LRAs）来激活潜伏病毒库细胞中的HIV病毒。许多lra可以从自然资源中获得，包括植物和海洋生物。在这篇综述中，我们提供了用于消除HIV潜伏期的天然产物的概述。
Abstract Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus (HIV) replication and transforming HIV infection from a fatal disease to a manageable chronic disease. However, the latent HIV reservoir persists in the body of HIV-infected individuals and is prone to reactivation. Therefore, the development of new treatment methods aimed at a complete cure for HIV is needed. The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as “shock and kill.” This strategy involves the use of latency-reversing agents (LRAs) to activate the HIV provirus in latent viral reservoir cells. Many LRAs can be obtained from natural resources, including plants and marine organisms. In this review, we provide an overview of natural products used to eliminate HIV latency.