Efficient Coupling Reaction of Quinone Monoacetal with Phenols Leading to Phenol Biaryls
Efficient Coupling Reaction of Quinone Monoacetal with Phenols Leading to Phenol Biaryls
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DOI：
10.1002/anie.201608013
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发表时间：
2016-12-12
影响因子：
16.6
通讯作者：
Kita, Yasuyuki
中科院分区：
文献类型：
--
作者：
Kamitanaka, Tohru;Morimoto, Koji;Kita, Yasuyuki
报道了一种简单有效的醌单缩醛与酚类化合物交叉偶联合成酚联物的方法。发现在1，1，1，3，3，3-六氟-2-丙醇中的布朗斯台德酸催化体系对于该转化特别有效。该反应可扩展到各种酚联芳基化合物的合成，包括空间位阻联芳基化合物，在温和的反应条件下，以高度区域特异性的方式，产率为58 - 90%。
A simple and efficient synthesis of phenol biaryls by the cross-couplings of quinone monoacetals (QMAs) and phenols is reported. The Bronsted acid catalytic system in 1,1,1,3,3,3-hexafluoro-2-propanol was found to be particularly efficient for this transformation. This reaction can be extended to the synthesis of various phenol biaryls, including sterically hindered biaryls, with yields ranging from 58 to 90% under mild reaction conditions and in a highly regiospecific manner.